The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a
dysregulated hyperinflammatory response. Areas covered Authors review evidence on IL-6 …

Background The prevalence of bacterial infection in patients with COVID-19 is low, however,
empiric antibiotic use is high. Risk stratification may be needed to minimize unnecessary …

Liver injury, characterized predominantly by elevated aspartate aminotransferase and
alanine aminotransferase, is a common feature of coronavirus disease 2019 (COVID‐19) …

Background: Atherosclerotic cardiovascular diseases are characterized by a dysregulated
inflammatory and thrombotic state, leading to devastating complications with increased …

Introduction The results of studies of tocilizumab (TCZ) in COVID‐19 are contradictory. Our
study aims to update medical evidence from controlled observational studies and …

ABSTRACT COVID-19 pneumonia has been associated with high rates of thrombo-embolic
complications, mostly venous thromboembolism (VTE), which is thought to be a combination …

Background Hospitalized COVID-19 patients are at high risk of venous thromboembolism
(VTE). Standard doses of anticoagulant prophylaxis may not be sufficiently effective for the …

Background: Baricitinib is a Janus kinase (JAK) inhibitor with a broader anti-inflammatory
activity than tocilizumab and an antiviral potential although no head-to-head trials are …