Continuous Flow Upgrading of Selected C2–C6 Platform Chemicals Derived from Biomass

R Gerardy, DP Debecker, J Estager, P Luis… - Chemical …, 2020 - ACS Publications
The ever increasing industrial production of commodity and specialty chemicals inexorably
depletes the finite primary fossil resources available on Earth. The forecast of population …

Role of biocatalysis in sustainable chemistry

RA Sheldon, JM Woodley - Chemical reviews, 2018 - ACS Publications
Based on the principles and metrics of green chemistry and sustainable development,
biocatalysis is both a green and sustainable technology. This is largely a result of the …

Continuous manufacturing–the Green Chemistry promise?

L Rogers, KF Jensen - Green chemistry, 2019 - pubs.rsc.org
Continuous manufacturing and Green Chemistry, are two promising approaches to
synthesis with underutilized potential that are gaining traction by the wider pharmaceutical …

Continuous flow biocatalysis

J Britton, S Majumdar, GA Weiss - Chemical Society Reviews, 2018 - pubs.rsc.org
The continuous flow synthesis of active pharmaceutical ingredients, value-added chemicals,
and materials has grown tremendously over the past ten years. This revolution in chemical …

The past, present and potential for microfluidic reactor technology in chemical synthesis

KS Elvira, XC i Solvas, RCR Wootton, AJ Demello - Nature chemistry, 2013 - nature.com
The past two decades have seen far-reaching progress in the development of microfluidic
systems for use in the chemical and biological sciences. Here we assess the utility of …

Aerobic copper-catalyzed organic reactions

SE Allen, RR Walvoord, R Padilla-Salinas… - Chemical …, 2013 - ACS Publications
The chemistry of copper is extremely rich because it can easily access Cu0, CuI, CuII, and
CuIII oxidation states allowing it to act through one-electron or two-electron processes. As a …

Process intensification for post-combustion CO2 capture with chemical absorption: A critical review

M Wang, AS Joel, C Ramshaw, D Eimer, NM Musa - Applied Energy, 2015 - Elsevier
The concentration of CO 2 in the atmosphere is increasing rapidly. CO 2 emissions may
have an impact on global climate change. Effective CO 2 emission abatement strategies …

End‐to‐end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation

S Mascia, PL Heider, H Zhang, R Lakerveld… - Angewandte …, 2013 - Wiley Online Library
For the past decade, the pharmaceutical industry has been under pressure to improve
efficiency, as rising costs outpaced the development of new pharmaceuticals.[1] A growing …

Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

KP Cole, JMC Groh, MD Johnson, CL Burcham… - Science, 2017 - science.org
Advances in drug potency and tailored therapeutics are promoting pharmaceutical
manufacturing to transition from a traditional batch paradigm to more flexible continuous …

Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis

RL Hartman, JP McMullen… - Angewandte Chemie …, 2011 - Wiley Online Library
The fine chemicals and pharmaceutical industries are transforming how their products are
manufactured, where economically favorable, from traditional batchwise processes to …