Folding and stability of ankyrin repeats control biological protein function
A Kumar, J Balbach - Biomolecules, 2021 - mdpi.com
Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins
are involved in protein-protein interaction in order to activate or suppress biological …
are involved in protein-protein interaction in order to activate or suppress biological …
A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder
SS Purushotham, NMN Reddy, MN D'Souza… - Experimental Brain …, 2022 - Springer
Intellectual disability (ID) and autism spectrum disorder (ASD) are neurodevelopmental
disorders that have become a primary clinical and social concern, with a prevalence of 2 …
disorders that have become a primary clinical and social concern, with a prevalence of 2 …
SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers
J Lilja, J Kaivola, JRW Conway, J Vuorio… - Nature …, 2024 - nature.com
The KRAS oncogene drives many common and highly fatal malignancies. These include
pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have …
pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have …
CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation
Abstract Ca2+/calmodulin-dependent kinase IIα (CaMKIIα) is essential for synaptic plasticity
and learning by decoding synaptic Ca2+ oscillations. Despite decades of extensive …
and learning by decoding synaptic Ca2+ oscillations. Despite decades of extensive …
SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
Actin-rich cellular protrusions direct versatile biological processes from cancer cell invasion
to dendritic spine development. The stability, morphology, and specific biological functions …
to dendritic spine development. The stability, morphology, and specific biological functions …
Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses
M Bucher, S Niebling, Y Han, D Molodenskiy… - Elife, 2021 - elifesciences.org
Members of the SH3-and ankyrin repeat (SHANK) protein family are considered as master
scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations …
scaffolds of the postsynaptic density of glutamatergic synapses. Several missense mutations …
A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners
RAS effectors specifically interact with GTP-bound RAS proteins to link extracellular signals
to downstream signaling pathways. These interactions rely on two types of domains, called …
to downstream signaling pathways. These interactions rely on two types of domains, called …
SHANK family on stem cell fate and development
SH3 and multiple ankyrin repeat domains protein (SHANK) 1, SHANK2, and SHANK3
encode a family of postsynaptic scaffolding proteins present at glutamatergic synapses and …
encode a family of postsynaptic scaffolding proteins present at glutamatergic synapses and …
Mutations affecting the N-terminal domains of SHANK3 point to different pathomechanisms in neurodevelopmental disorders
D Woike, E Wang, D Tibbe, F Hassani Nia, AV Failla… - Scientific Reports, 2022 - nature.com
Shank proteins are major scaffolds of the postsynaptic density of excitatory synapses.
Mutations in SHANK genes are associated with autism and intellectual disability. The effects …
Mutations in SHANK genes are associated with autism and intellectual disability. The effects …
Ras, RhoA, and vascular pharmacology in neurodevelopment and aging
R Nussinov, H Jang, F Cheng - Neurochemistry International, 2024 - Elsevier
Abstract Small GTPases Ras, Rac, and RhoA are crucial regulators of cellular functions.
They also act in dysregulated cell proliferation and transformation. Multiple publications …
They also act in dysregulated cell proliferation and transformation. Multiple publications …