Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …

MYCN is amplified in 20% to 25% of neuroblastoma, and MYCN-amplified neuroblastoma
contributes to a large percent of pediatric cancer–related deaths. Therapy improvements for …

The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

Background: Splicing factors are essential for nascent pre-mRNA processing and critical in
cancer progression, suggesting that proteins with splicing functions represent potential …

Coordination compounds-based drugs are crucial in targeting various diseases due to their
distinct structural order. They also show a significant role in biological systems, including …

Simple Summary Glioblastoma (GBM) is a fatal brain cancer. Over 50% of GBM tumors
overexpress EGFR, a protein involved in tumor progression and drug resistance. The …

Mitochondria play a fundamental role in the energetics of cardiac cells. Moreover,
mitochondria are involved in cardiac ischemia/reperfusion injury by opening the …

Exchange proteins directly activated by cAMP (Epac) proteins are implicated in a wide range
of cellular functions including oxidative stress and cell survival. Mitochondrial-dependent …

From previous studies, it is evident that metal–organic gold (I) complexes have
antiproliferative activities. The aim of this study is not only to find new anticancer agents but …