The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …

Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …

Identifying tumor antigen-specific T cells from cancer patients has important implications for
immunotherapy diagnostics and therapeutics. Here, we show that CD103+ CD39+ tumor …

The skin is the outermost layer of the body with an extensive surface area of approximately
1· 8 m2, and is the first line of defence against a multitude of external pathogens and …

CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …

Tissue-resident memory T cells (TRMs) in mice mediate optimal protective immunity to
infection and vaccination, while in humans, the existence and properties of TRMs remain …

The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …

BACKGROUND Sphingosine 1-phosphate (S1P), a product of membrane sphingolipid
metabolism, is secreted and acts through G protein–coupled S1P receptors (S1PRs) in …

CD69 is a membrane‐bound, type II C‐lectin receptor. It is a classical early marker of
lymphocyte activation due to its rapid appearance on the surface of the plasma membrane …

Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …