Transposable elements (TEs) are mobile DNA sequences that propagate within genomes.
Through diverse invasion strategies, TEs have come to occupy a substantial fraction of …

Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …

Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …

All life forms defend their genome against DNA invasion. Eukaryotic cells recognize
incoming DNA and limit its transcription through repressive chromatin modifications. The …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Transposable elements (TEs) are mobile DNA sequences that colonize genomes and
threaten genome integrity. As a result, several mechanisms appear to have emerged during …

Transposable elements, also known as transposons, are now recognized not only as
parasitic DNA, the spread of which in the genome must be controlled by the host, but also as …

Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …

Throughout evolution primate genomes have been modified by waves of retrotransposon
insertions,,. For each wave, the host eventually finds a way to repress retrotransposon …

In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and
stably distributed across the genome, with local, cell-type-specific regulation directed by …