Biochemical systems are among of the oldest application areas of mathematical modeling.
Spanning a time period of over one hundred years, the repertoire of options for structuring a …

This year we celebrate the 150th anniversary of the law of mass action. This law is often
assumed to have been “there” forever, but it has its own history, background, and a definite …

Modern instruments generate BIG DATA that require information extraction before they can
be used. A hybrid modelling framework for that is presented and illustrated. Its purpose is to …

The editors of J. Chemometrics have been kind enough to invite me to outline some
directions, which I think young chemometricians could find interesting for the future. This …

New multivariate calibration methods and other processes are being developed that require
selection of multiple tuning parameter (penalty) values to form the final model. With one or …

The β‐adrenergic response is impaired in failing hearts. When studying β‐adrenergic
function in vitro, the half‐maximal effective concentration (EC 50) is an important measure of …

Abstract Physics-based Finite Element Methods models can be used to investigate the
electrical conditions in submerged arc furnaces (SAFs). However, their explicit solution may …

One of the most important properties of a mathematical model is the ability to make
predictions: to predict that which has not yet been measured. Such predictions can …

The increasing complexity of mathematical models of complex systems like living cells has
created a need for methods to reduce computational demand, maintain overview of the …

The estimation of parameters in even moderately large biological systems is a significant
challenge. This challenge is greatly exacerbated if the mathematical formats of appropriate …