Numerous agents targeting various phosphatidylinositol 3-kinase (PI3K) pathway
components, including PI3K, AKT and mTOR, have been tested in oncology clinical trials …

Cancer is often considered a genetic disease. However, much of the enormous plasticity of
cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and …

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

Somatic mutations have been extensively characterized in breast cancer, but the effects of
these genetic alterations on the proteomic landscape remain poorly understood. Here we …

Somatic mutations in TEK, the gene encoding endothelial cell tyrosine kinase receptor TIE2,
cause more than half of sporadically occurring unifocal venous malformations (VMs). Here …

SILAC is based on direct addition of selected stable isotope amino acids into the cell culture
medium, allowing superior quantitative analysis of the cellular proteome compared to other …

INTRODUCTION Tumor genome sequencing has revealed that, beyond a few commonly
mutated genes, most mutations that affect cancer genomes are rare. To interpret these rare …

The class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that transduce a host of
cellular signals and regulate a broad range of essential functions including growth …

Background: The current analysis was performed to evaluate the impact of PIK3CA hotspot
mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) …

Despite the immense importance of enzyme–substrate reactions, there is a lack of general
and unbiased tools for identifying and prioritizing substrate proteins that are modified by the …