Diabetes is associated with numerous comorbidities, one of which is increased vulnerability
to infections. This review will focus on how diabetes mellitus (DM) affects the immune system …

Self-reactive T cells experience chronic antigen exposure but do not exhibit signs of
exhaustion. Here, we investigated the mechanisms for sustained, functioning autoimmune …

The involvement of cellular senescence in the initiation and propagation of diseases is
clearly characterized, making the elimination of senescent cells essential to treat age-related …

Background Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease
resulting from an immune-mediated destruction of pancreatic insulin-secreting β cells. A …

Background Immunity and inflammation may be essential to the pathogenesis of dementia.
However, the association of immune-mediated diseases with the risk of incident dementia …

Abstract Treatment of patients with recent-onset type 1 diabetes with an anti-CD3 antibody
leads to the transient stabilization of C-peptide levels in responder patients. Partial efficacy …

Introduction Inflammation and cell death play an important role in the pathogenesis of
diabetic retinopathy. Previously we observed sustained activation of pro-inflammatory …

Background Around 10% of people with HIV (PWH) exhibit a low-level viremia (LLV) under
antiretroviral therapy (ART). However, its origin and clinical significance are largely …

Introduction Altered serum levels of growth hormones, adipokines, and exocrine pancreas
enzymes have been individually linked with type 1 diabetes (T1D). We collectively evaluated …

Purpose Developmental abnormalities in B cells is one of the key players in autoimmune
diabetes, but little is known about its role in latent autoimmune diabetes in adults (LADA) …