Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications

BJB Nelson, J Wilson, JD Andersson, F Wuest - Pharmaceuticals, 2023 - mdpi.com
This article highlights recent developments of SPECT and PET diagnostic imaging
surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the …

Pembrolizumab as monotherapy in locally advanced cutaneous squamous cell carcinoma

A Giri, JR Bauman - Expert Review of Anticancer Therapy, 2022 - Taylor & Francis
Introduction Outcomes for patients with advanced cutaneous squamous cell carcinoma
(cSCC) are poor, however recent approvals in programmed death-1 (PD-1) checkpoint …

A finite element method for modeling diffusion of alpha‐emitting particles in tissue

IP Zhang, GN Cohen, AL Damato - Medical Physics, 2024 - Wiley Online Library
Abstract Background Diffusing alpha‐emitters Radiation Therapy (“DaRT”) is a promising
new modality for the treatment of solid tumors. Interstitial sources containing 224Ra are …

Dual targeting with 224Ra/212Pb-conjugates for targeted alpha therapy of disseminated cancers: A conceptual approach

A Juzeniene, VY Stenberg, ØS Bruland… - Frontiers in …, 2023 - frontiersin.org
Metastases are the primary cause of death among cancer patients and efficacious new
treatments are sorely needed. Targeted alpha-emitting radiopharmaceuticals that are highly …

Diffusing alpha particles radiation treatment optimization in clinical settings

G Feliciani - 2024 - amsdottorato.unibo.it
Alpha-particle emitters, notably used in 224Ra-DaRT, have emerged as effective in
overcoming radiation resistance and providing targeted cancer therapy. These emitters …

[PDF][PDF] Verification of GEANT4-DNA and a simplified DNA model

Y Shi - 2022 - research-information.bris.ac.uk
Cancer is becoming the second leading cause of death in the world, thus the development
of effective treatment for cancer is important. Radiation therapy is a method of treating …