Thalidomide was first marketed in 1957 but soon withdrawn because of its notorious
teratogenicity. Studies on the mechanism of action of thalidomide revealed the pleiotropic …

Since the 1960s, drugs have been known to cause teratogenic effects in humans. Such
teratogenicity has been postulated to be influenced by genetics. The aim of this review was …

Introduction Nitric oxide (NO) is a molecule with multiple functions. Several drugs involve the
modulation of NO levels in their mechanism of action. NO is mainly produced in vessels by …

Thalidomide is widely used for several diseases; however, it causes malformations in
embryos exposed during pregnancy. The complete understanding of the mechanisms by …

The identification of thalidomide–Cereblon-induced SALL4 degradation has brought new
understanding for thalidomide embryopathy (TE) differences across species. Some …

Nausea and vomiting of pregnancy (NVP) remains difficult to treat. Last century, thalidomide
was used to alleviate NVP, but it caused teratogenesis by interfering with angiogenesis. The …

Background Several meta-analyses of the relationship between endothelial nitric oxide
synthase (eNOS) T-786C gene polymorphism and chronic kidney disease (CKD) have been …

Purpose To investigate the association between single nucleotide polymorphisms (SNPs) in
endothelial nitric oxide synthase (eNOS) and interleukin-8 (IL-8) genes and risk of …

Thalidomide embryopathy (TE) has affected more than 10,000 babies worldwide. The
hypothesis of antiangiogenesis as the teratogenic mechanism of thalidomide has been …

Thalidomide is a drug used worldwide for several indications, but the molecular
mechanisms of its teratogenic property are not fully understood. Studies in animal models …