Long non-coding RNAs (lncRNAs) are diverse transcription products emanating from
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …

Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are
different types of non-coding RNAs that modulate complex molecular and cellular …

Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …

Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a
pathological disorganized wound healing process with chronic inflammation. The TGF …

Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …

Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

While there exist some long non-coding RNAs (lncRNAs) that are structurally similar to
mRNAs (capped, spliced, poly a tail), not all of the lncRNAs exhibit these features …

Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which
comprise the bulk of the genome, is important for understanding virtually every hallmark of …