The prevalence of multiple sclerosis (MS) and the age of affected patients are increasing
owing to increased longevity of the general population and the availability of effective …

Early evaluation of treatment response and prediction of disease evolution are key issues in
the management of people with multiple sclerosis (MS). In the past 20 years, MRI has …

Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …

Overactivation of microglia is associated with most neurodegenerative diseases. In this
study we examined whether PET-measurable innate immune cell activation predicts multiple …

Objective A major challenge in multiple sclerosis (MS) research is the understanding of
silent progression and Progressive MS. Using a novel method to accurately capture upper …

The spinal cord is frequently affected in multiple sclerosis (MS), causing motor, sensory and
autonomic dysfunction. A number of pathological abnormalities, including demyelination …

Inflammatory myelopathies can manifest with a combination of motor, sensory and
autonomic dysfunction of variable severity. Depending on the underlying etiology, the …

Spinal cord involvement is a hallmark feature of multiple sclerosis, neuromyelitis optica with
AQP4 antibodies and MOG-antibody disease. In this cross-sectional study we use …

Importance Although magnetic resonance imaging (MRI) is useful for monitoring disease
dissemination in space and over time and excluding multiple sclerosis (MS) mimics, there …

Background and Objectives Progression independent of relapse activity (PIRA) is a crucial
determinant of overall disability accumulation in multiple sclerosis (MS). Accelerated brain …