[HTML][HTML] Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome

HN Thirimanne, D Almiron-Bonnin, N Nuechterlein… - Cell genomics, 2024 - cell.com
Meningiomas, although mostly benign, can be recurrent and fatal. World Health
Organization (WHO) grading of the tumor does not always identify high-risk meningioma …

Visualizing genomic characteristics across an RNA-Seq based reference landscape of normal and neoplastic brain

S Arora, F Szulzewsky, M Jensen, N Nuechterlein… - Scientific Reports, 2023 - nature.com
In order to better understand the relationship between normal and neoplastic brain, we
combined five publicly available large-scale datasets, correcting for batch effects and …

OCTAD: an open workspace for virtually screening therapeutics targeting precise cancer patient groups using gene expression features

B Zeng, BS Glicksberg, P Newbury, E Chekalin… - Nature protocols, 2021 - nature.com
As the field of precision medicine progresses, treatments for patients with cancer are starting
to be tailored to their molecular as well as their clinical features. The emerging cancer …

CVCDAP: an integrated platform for molecular and clinical analysis of cancer virtual cohorts

X Guan, M Cai, Y Du, E Yang, J Ji… - Nucleic acids research, 2020 - academic.oup.com
Recent large-scale multi-omics studies resulted in quick accumulation of an overwhelming
amount of cancer-related data, which provides an unprecedented resource to interrogate …

Computational resources for oncology research: a comprehensive analysis

K Sheikh, A Ramlal, FN Khan - Computational Intelligence in Oncology …, 2022 - Springer
Despite the efforts and clinical trials in the past for the production of novel and promising
therapeutics against cancer, it remains a major challenge leading to mass morbidity and …

Translating basic science discoveries into improved outcomes for glioblastoma

PB Dirks, MR Gilbert, EC Holland, EA Maher… - Clinical Cancer …, 2020 - AACR
Members of the scientific and clinical neuro-oncology community met in April 2019 to
discuss the current challenges and opportunities associated with translating basic science …

[HTML][HTML] An RNA seq-based reference landscape of human normal and neoplastic brain

S Arora, F Szulzewsky, M Jensen… - Research …, 2023 - ncbi.nlm.nih.gov
In order to better understand the relationship between normal and neoplastic brain, we
combined five publicly available large-scale datasets, correcting for batch effects and …

Graphical data mining of cancer mechanisms with SEMA

M Solmaz, A Lane, B Gonen, O Akmamedova… - …, 2019 - academic.oup.com
Motivation An important goal of cancer genomics initiatives is to provide the research
community with the resources for the unbiased query of cancer mechanisms. Several …

[HTML][HTML] Transcriptomic landscape identifies two unrecognized ependymoma subtypes and novel pathways in medulloblastoma

S Arora, N Nuechterlein, M Jensen, G Glatzer… - …, 2024 - pmc.ncbi.nlm.nih.gov
Medulloblastoma and ependymoma are prevalent pediatric central nervous system tumors
with significant molecular and clinical heterogeneity. We collected bulk RNA sequencing …

Visual Analytics System Designs for Using Scientific Evidence in Medical Research

이용석 - 2022 - s-space.snu.ac.kr
Evidence-based medicine," the conscientious, explicit, and judicious use of current best
evidence in healthcare and medical research"[98], is one of the most widely accepted …