The global increase in antimicrobial drug resistance has dramatically reduced the
effectiveness of traditional antibiotics. Structurally diverse antibiotics are urgently needed to …

This review describes the discovery, structure, activity, engineered constructs, and
applications of KR-12, the smallest antibacterial peptide of human cathelicidin LL-37, the …

Given the widespread demand for novel antibacterial agents, we modified a cell-penetrating
peptide (KFF) 3K to transform it into an antibacterial peptide. Namely, we inserted a …

Antibiotic resistance is a major global health threat, necessitating the development of new
treatments and diverse molecules to combat severe infections and preserve the efficacy of …

In recent years, bacterial resistance to conventional antibiotics has become a major concern
in the medical field. The global misuse of antibiotics in clinics, personal use, and agriculture …

Cell-penetrating peptides (CPPs) are a diverse group of peptides, typically composed of 4 to
40 amino acids, known for their unique ability to transport a wide range of substances—such …

The emergence of bacterial resistance has posed a significant challenge to clinical
antimicrobial treatment, rendering commonly used antibiotics ineffective. The development …

Rationale: Antimicrobial peptide LL-37 has been recognized as a favorable alternative to
antibiotics due to its broad antibacterial spectrum, low resistance development and diverse …

The misuse and overuse of antibiotics led to the development of bacterial resistance to
existing aminoglycoside (AMG) antibiotics and limited their use. Consequently, there is a …

The identification of novel candidate molecules with the potential to revolutionize the
treatment of breast cancer holds profound clinical significance. Macropin (Mac)-1, derived …