Targeting non-coding RNAs to overcome cancer therapy resistance
BQ Chen, MP Dragomir, C Yang, Q Li, D Horst… - Signal transduction and …, 2022 - nature.com
It is now well known that non-coding RNAs (ncRNAs), rather than protein-coding transcripts,
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …
Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
one of the most frequently dysregulated signaling pathways observed in cancer patients that …
[HTML][HTML] Circular RNA-protein interactions: functions, mechanisms, and identification
Circular RNAs (circRNAs) are covalently closed, endogenous RNAs with no 5′ end caps or
3′ poly (A) tails. These RNAs are expressed in tissue-specific, cell-specific, and …
3′ poly (A) tails. These RNAs are expressed in tissue-specific, cell-specific, and …
[HTML][HTML] Review on circular RNAs and new insights into their roles in cancer
X Tang, H Ren, M Guo, J Qian, Y Yang, C Gu - … and structural biotechnology …, 2021 - Elsevier
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …
Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA
P Wu, Y Mo, M Peng, T Tang, Y Zhong, X Deng… - Molecular cancer, 2020 - Springer
Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression
C Xue, G Li, J Lu, L Li - Signal transduction and targeted therapy, 2021 - nature.com
Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in
eukaryotes and viruses. They can function by regulating target gene expression, linear RNA …
eukaryotes and viruses. They can function by regulating target gene expression, linear RNA …
Going circular: history, present, and future of circRNAs in cancer
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
Y Peng, Y Xu, X Zhang, S Deng, Y Yuan, X Luo… - Molecular cancer, 2021 - Springer
Abstract Background Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical
role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a …
role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a …
Circular RNA translation, a path to hidden proteome
Functional proteins in the cell are translated from the messenger RNA (mRNA) molecules,
constituting less than 5% of the cellular transcriptome. The majority of the RNA molecules in …
constituting less than 5% of the cellular transcriptome. The majority of the RNA molecules in …
circ-EIF6 encodes EIF6-224aa to promote TNBC progression via stabilizing MYH9 and activating the Wnt/beta-catenin pathway
The protein-coding ability of circular RNAs (circRNAs) has recently been a hot topic, but the
expression and roles of protein-coding circRNAs in triple-negative breast cancer (TNBC) …
expression and roles of protein-coding circRNAs in triple-negative breast cancer (TNBC) …