Calpains, a family of Ca2+-dependent cytosolic cysteine proteases, can modulate their
substrates' structure and function through limited proteolytic activity. In the human genome …

The evolution of the IGF binding protein (IGFBP) gene family has been difficult to resolve.
Both chromosomal and serial duplications have been suggested as mechanisms for the …

One of the changes found in the brain in Alzheimer's disease (AD) is increased calpain,
derived from calcium dysregulation, oxidative stress, and/or neuroinflammation, which are …

The study of unfolded protein regions has gained importance because of their prevalence
and important roles in various cellular functions. These regions have characteristically high …

The metzincin metalloproteinase pregnancy-associated plasma protein-A (PAPP-A,
pappalysin-1, EC 3.4. 24.79) specifically cleaves insulin-like growth factor binding protein …

The germinal matrix of human brain gives rise to oligodendrocytes and astrocytes after mid‐
gestation. Hemorrhage in the germinal matrix of premature infants is associated with …

Introduction: The signaling pathways of the insulin-like growth factors (IGFs) have been
implicated in the aetiology of type 2 diabetes (T2D) and a number of therapeutic modalities …

Calpains are cytoplasmic Ca2+-regulated cysteine proteases that may regulate insulin-like
growth factor (IGF)-independent actions of insulin-like growth factor binding proteins …

Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously
distributed across most cell types and vertebrate species. Calpains play a role in cell …

Activity induced skeletal muscle adaptation has been suggested to be mediated largely by
intrinsic factors, such as insulin-like growth factor (IGF)-I. IGF-I stimulates muscle glucose …