The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …

Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …

Natural products and their molecular frameworks have a long tradition as valuable starting
points for medicinal chemistry and drug discovery. Recently, there has been a revitalization …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Biologically active molecules can be identified through the screening of small-molecule
libraries. Deficiencies in current compound collections are evidenced by the continuing …

Which compound classes are best suited as probes and tools for chemical biology research
and as inspiration for medicinal chemistry programs? Chemical space is enormously large …

This review seeks to provide a timely survey of the scope and limitations of cheminformatics
methods in natural product‐based drug discovery. Following an overview of data resources …

STRONGHOLDS FOR DRUG DISCOVERY Historically, natural products (NPs) have played
a key role in the development of chemotherapy, 1, 2 and to this very day numerous marketed …

Small molecule modulators of biological function can be discovered by the screening of
compound libraries. However, it became apparent that some human disease related targets …