Simple Summary Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-
cancer drugs, with twelve agents in current clinical use. Despite recent successes, many …

Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and
enhanced effector functions, including highly efficient pathogen neutralisation and …

IgG3 comprises only a minor fraction of IgG and has remained relatively understudied until
recent years. Key physiochemical characteristics of IgG3 include an elongated hinge region …

Immunoglobulin G (IgG) fragment crystallizable (Fc) glycosylation modulates effector
functions such as antibody-dependent cellular cytotoxicity and complement-dependent …

The importance and effect of Fc glycosylation of monoclonal antibodies with regard to
biological activity is widely discussed and has been investigated in numerous studies. Fc …

Sindbis virus (SINV; family Togaviridae, genus Alphavirus) is an enveloped RNA virus
widely distributed in Eurasia, Africa, Oceania and Australia. SINV is transmitted among its …

The loss of tolerance to self-antigens is the unequivocal “red line” of autoimmunity: both
development of autoreactive T and B cells and production of polyclonal autoantibodies …

Autoimmune neuropathy associated with antibodies against pan-neurofascin is a new
subtype of nodo-paranodopathy. It is relevant because it is associated with high morbidity …