The advent of high-throughput sequencing uncovered that our genome is pervasively
transcribed into RNAs that are seemingly not translated into proteins. It was also found that …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Ageing is the predominant risk factor for cardiovascular diseases and contributes to a
significantly worse outcome in patients with acute myocardial infarction. MicroRNAs …

Both DNA and chromatin need to be duplicated during each cell division cycle. Replication
happens in the context of defects in the DNA template and other forms of replication stress …

The processes regulating telomere function have major impacts on fundamental issues in
human cancer biology. First, active telomere maintenance is almost always required for full …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …

Cells are constantly suffering genotoxic stresses that affect the integrity of our genetic
material. Genotoxic insults must be repaired to avoid the loss or inappropriate transmission …

Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …

The total number of protein-coding genes in the human genome is not significantly higher
than those in much simpler eukaryotes, despite a general increase in genome size …

The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of key
biological targets by associating with nearly 200 regulatory proteins to form highly specific …