Oxidation of drugs during drug product development: problems and solutions

A Gabrič, Ž Hodnik, S Pajk - Pharmaceutics, 2022 - mdpi.com
Oxidation is the second most common degradation pathway for pharmaceuticals, after
hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex …

Analysis and removal of pharmaceutical residues from wastewater using membrane bioreactors: a review

C Femina Carolin, P Senthil Kumar… - Environmental …, 2021 - Springer
Pharmaceutical compounds such antibiotics, anti-inflammatories, psychotropics, human
drugs, hormones, anticonvulsants, antidepressants, veterinary drugs and steroids occur …

Application of advanced environmentally benign assessment tools in determining ternary cardiovascular drug combination by RP-HPLC with analytical quality by …

KP Kannaiah, HK Chanduluru, RH Obaydo… - Sustainable Chemistry …, 2023 - Elsevier
Assessing any analytical method is becoming an important aspect for showcasing its
importance and impact on the environment. The present work aimed to showcase different …

Integrative AQbD, up-to-date greenness, and whiteness tools for evaluation of a sustainable RP-HPLC method used for simultaneous separation of triple …

KP Kannaiah, HK Chanduluru, HM Lotfy… - Sustainable Chemistry …, 2023 - Elsevier
The present study was designed to develop and validate a simple and fast RP-HPLC
method for simultaneously evaluating hydrochlorothiazide (HCTZ), amlodipine besylate …

Talc concentration effect on shelf life of acetaminophen tablets

MM Calvino, G Cavallaro, G Lazzara… - Journal of Thermal …, 2023 - Springer
Excipients in pharmaceutical formulations are inactive ingredient from the biological point of
view, but they have a key role in the preparation, and they can alter the stability of the active …

[HTML][HTML] Theoretical and experimental model of molecularly imprinted polymer surface microenvironment for selective stationary phase–exemplary of S-pramipexole …

M Sobiech, J Giebułtowicz, M Woźnica, I Jaworski… - Microchemical …, 2022 - Elsevier
In this paper, the theoretical models of the molecularly imprinted polymer surface
microenvironment were investigated. S-Pramipexole was used as a model drug and its …

Application of co-amorphous technology for improving the physicochemical properties of amorphous formulations

R Mizoguchi, H Waraya, Y Hirakura - Molecular pharmaceutics, 2019 - ACS Publications
Co-amorphous technology was recently introduced to stabilize drugs in the amorphous state
for drug development. We examined the predictability of the formation of co-amorphous …

Matrix systems for oral drug delivery: Formulations and drug release

G Vasvári, J Kalmár, P Veres, M Vecsernyés… - Drug Discovery Today …, 2018 - Elsevier
In this current article matrix formulations for oral drug delivery are reviewed. Conventional
dosage forms and novel applications such as 3D printed matrices and aerogel matrices are …

Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and …

AY Rybkin, SV Kurmaz, EA Urakova, NV Filatova… - Pharmaceutics, 2023 - mdpi.com
A series of nanoparticles (NPs) with a hydrodynamic radius from 20 to 100 nm in PBS was
developed over the solubilization of hydrophobic dye methyl pheophorbide a (chlorin e6 …

A sustainable approach for the degradation kinetics study and stability assay of the SARS-CoV-2 oral antiviral drug Molnupiravir

FH Edrees, ME Draz, AS Saad, SF Hammad… - Scientific Reports, 2023 - nature.com
Molnupiravir (MPV) is the first direct-acting oral antiviral drug that effectively decreases
nasopharyngeal infections with SARS-CoV-2 virus. The stability of MPV was tested by …