For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-
CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and …

Early prediction of cardiotoxicity is critical for drug development. Current animal models
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …

The need to develop new tools and increase capacity to test pharmaceuticals and other
chemicals for potential adverse impacts on human health and the environment is an active …

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for
assessment of drug-induced arrhythmias and are being considered for use under the …

Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical
market. Several chemotherapeutic compounds have been noted for their propensities to …

Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …

Recent innovations in differentiating cardiomyocytes from human induced pluripotent stem
cells (hiPSCs) have unlocked a viable path to creating in vitro cardiac models. Currently …