For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

Engineered human cardiac tissues have been utilized for various biomedical applications,
including drug testing, disease modeling, and regenerative medicine. However, the …

Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-
CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and …

Early prediction of cardiotoxicity is critical for drug development. Current animal models
raise ethical and translational questions, and have limited accuracy in clinical risk prediction …

The need to develop new tools and increase capacity to test pharmaceuticals and other
chemicals for potential adverse impacts on human health and the environment is an active …

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for
assessment of drug-induced arrhythmias and are being considered for use under the …

Drug-induced cardiotoxicity arises primarily when a compound alters the
electrophysiological properties of cardiomyocytes. Features of intracellular action potentials …

Drug-induced Torsade-de-Pointes (TdP) has been responsible for the withdrawal of many
drugs from the market and is therefore of major concern to global regulatory agencies and …