Controlled immune responses to infection and injury involve complex molecular signalling
networks with coordinated and often opposing actions. Eicosanoids and related bioactive …

The classical pathway of interferon-γ-dependent activation of macrophages by T helper 1
(TH1)-type responses is a well-established feature of cellular immunity to infection with …

In terms of both phenotype and function, macrophages have remarkable heterogeneity,
which reflects the specialization of tissue-resident macrophages in microenvironments as …

Obesity induces an insulin-resistant state in adipose tissue, liver, and muscle and is a strong
risk factor for the development of type 2 diabetes mellitus. Insulin resistance in the setting of …

The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …

Metabolism and immunity are two fundamental systems of metazoans. The presence of
immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing …

The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely
associated with a state of low-grade inflammation,. In adipose tissue chronic overnutrition …

Purpose Macrophages are highly plastic cells. Under different stimuli, macrophages can be
polarized into several different subsets. Two main macrophage subsets have been …

Macrophages undergoing M1-versus M2-type polarization differ significantly in their cell
metabolism and cellular functions. Here, global quantitative time-course proteomics and …