Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

Neutrophil migration and its role during inflammation has been the focus of increased
interest in the past decade. Advances in live imaging and the use of new model systems …

Endotoxins and exotoxins are among the most potent bacterial inducers of cytokines. During
infectious processes, the production of inflammatory cytokines including tumor necrosis …

Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in
both hospital and community settings, especially with the widespread emergence of virulent …

Staphylococcus aureus secretes a number of host-injurious toxins, among the most
prominent of which is the small β-barrel pore-forming toxin α-hemolysin. Initially named …

Inflammasomes are multiprotein complexes that activate caspase-1, which leads to
maturation of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 and the …

Staphylococcus aureus causes many types of human infections and syndromes—most
notably skin and soft tissue infections. Abscesses are a frequent manifestation of S. aureus …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinically severe
respiratory disorders, and there are currently no Food and Drug Administration–approved …

The inflammasomes are multiprotein complexes sensing tissue damage and infectious
agents to initiate innate immune responses. Different inflammasomes containing distinct …

Staphylococcus aureus colonization contributes to skin inflammation in diseases such as
atopic dermatitis, but the signaling pathways involved are unclear. Herein, epicutaneous S …