Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential
K Butler, AR Banday - Journal of Hematology & Oncology, 2023 - Springer
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine
deaminases involved in innate and adaptive immunity. However, some APOBEC family …
deaminases involved in innate and adaptive immunity. However, some APOBEC family …
Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways
S Oh, E Bournique, D Bowen, P Jalili… - Nature …, 2021 - nature.com
APOBEC3A is a cytidine deaminase driving mutagenesis in tumors. While APOBEC3A-
induced mutations are common, APOBEC3A expression is rarely detected in cancer cells …
induced mutations are common, APOBEC3A expression is rarely detected in cancer cells …
Coregulation of pathways in lung cancer patients with EGFR mutation: therapeutic opportunities
Epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma are a frequent
class of driver mutations. Single EGFR tyrosine kinase inhibitor (TKI) provides substantial …
class of driver mutations. Single EGFR tyrosine kinase inhibitor (TKI) provides substantial …
Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma
NJ Smith, I Reddin, P Policelli, S Oh, N Zainal… - The EMBO …, 2025 - embopress.org
Two APOBEC DNA cytosine deaminase enzymes, APOBEC3A and APOBEC3B, generate
somatic mutations in cancer, thereby driving tumour development and drug resistance. Here …
somatic mutations in cancer, thereby driving tumour development and drug resistance. Here …
Aberrant apobec3b expression in breast cancer is linked to proliferation and cell cycle phase
PA Roelofs, MAM Timmermans, B Stefanovska… - Cells, 2023 - mdpi.com
APOBEC3B (A3B) is aberrantly overexpressed in a subset of breast cancers, where it
associates with advanced disease, poor prognosis, and treatment resistance, yet the causes …
associates with advanced disease, poor prognosis, and treatment resistance, yet the causes …
NF-κB in cell deaths, therapeutic resistance and nanotherapy of tumors: recent advances
X Wu, L Sun, F Xu - Pharmaceuticals, 2023 - mdpi.com
The transcription factor nuclear factor-κB (NF-κB) plays a complicated role in multiple
tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and …
tumors. Mounting evidence demonstrates that NF-κB activation supports tumorigenesis and …
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis
The cytidine deaminase APOBEC3B (A3B) is an endogenous inducer of somatic mutations
and causes chromosomal instability by converting cytosine to uracil in single-stranded DNA …
and causes chromosomal instability by converting cytosine to uracil in single-stranded DNA …
APOBEC3B is overexpressed in cervical cancer and promotes the proliferation of cervical cancer cells through apoptosis, cell cycle, and p53 pathway
Z Wei, J Gan, X Feng, M Zhang, Z Chen, H Zhao… - Frontiers in …, 2022 - frontiersin.org
Objective APOBEC3B (A3B), a member of the APOBEC family of cytidine deaminases, has
been gradually regarded as a key cancerous regulator. However, its expression and …
been gradually regarded as a key cancerous regulator. However, its expression and …
APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer
NMG Garcia, JN Becerra, BJ McKinney, AV DiMarco… - …, 2024 - pmc.ncbi.nlm.nih.gov
APOBEC mutagenesis is one of the most common endogenous sources of mutations in
human cancer and is a major source of genetic intratumor heterogeneity. High levels of …
human cancer and is a major source of genetic intratumor heterogeneity. High levels of …