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[HTML][HTML] Revisited metabolic control and reprogramming cancers by means of the warburg effect in tumor cells
Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …
Altered cellular metabolism in gliomas—An emerging landscape of actionable co-dependency targets
Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …
technological advances, new insights into the molecular mechanisms underlying glioma …
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
Abstract l-Glutamine (Gln) functions physiologically to balance the carbon and nitrogen
requirements of tissues. It has been proposed that in cancer cells undergoing aerobic …
requirements of tissues. It has been proposed that in cancer cells undergoing aerobic …
Glioblastoma metabolism: insights and therapeutic strategies
C Bernhard, D Reita, S Martin, N Entz-Werle… - International Journal of …, 2023 - mdpi.com
Tumor metabolism is emerging as a potential target for cancer therapies. This new approach
holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is …
holds particular promise for the treatment of glioblastoma, a highly lethal brain tumor that is …
Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype
S Rodic, MD Vincent - International journal of cancer, 2018 - Wiley Online Library
Cancer cells exhibit a wide range of metabolic phenotypes, ranging from strict aerobic
glycolysis to increased mitochondrial respiration. The cause and utility of this metabolic …
glycolysis to increased mitochondrial respiration. The cause and utility of this metabolic …
Metabolic Rewiring in Glioblastoma Cancer: EGFR, IDH and Beyond
Glioblastoma multiforme (GBM), a highly invasive and incurable tumor, is the humans'
foremost, commonest, and deadliest brain cancer. As in other cancers, distinct combinations …
foremost, commonest, and deadliest brain cancer. As in other cancers, distinct combinations …
[HTML][HTML] Metabolic abnormalities in glioblastoma and metabolic strategies to overcome treatment resistance
Glioblastoma (GBM) is the most common and aggressive primary brain tumor and is nearly
universally fatal. Targeted therapy and immunotherapy have had limited success in GBM …
universally fatal. Targeted therapy and immunotherapy have had limited success in GBM …
Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways
Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the
large majority of diffuse gliomas and are associated with hypermethylation of DNA and …
large majority of diffuse gliomas and are associated with hypermethylation of DNA and …
[HTML][HTML] Molecular targeted therapies in glioblastoma multiforme: a systematic overview of global trends and findings
This systematic review assesses current molecular targeted therapies for glioblastoma
multiforme (GBM), a challenging condition with limited treatment options. Using PRISMA …
multiforme (GBM), a challenging condition with limited treatment options. Using PRISMA …