Phagocytosis of tubercle bacilli by antigen‐presenting cells in human lung alveoli initiates a
complex infection process by Mycobacterium tuberculosis and a potentially protective …

The tuberculin skin test, which involves monitoring the immune reaction to an injection of
purified protein derivative (PPD), has been the most widely used method for detecting …

Background Many countries offer a second BCG vaccination to prevent tuberculosis,
although there is little evidence of whether this confers additional protection. BCG …

The secreted Mycobacterium tuberculosis protein, ESAT6, has been studied extensively in
pathogenicity and vaccine experiments. Despite these studies little is known about the …

Currently, there is only one licensed vaccine against tuberculosis (TB), the Bacillus Calmette–
Guérin (BCG). Despite its protective efficacy against TB in children, BCG has failed to protect …

T-cell-epitope map** has emerged as one of the most powerful new drug discovery tools
for a range of biomedical applications. Initially, T-cell-epitope discovery was applied to the …

Some microorganisms belonging to the Mycobacterium tuberculosis (Mtb) complex produce
an airborne infectious disease, called tuberculosis (TB). Robert Koch discovered this …

The variation in sequence and length in the C-terminal region among members of the
unique PE (Pro-Glu) and PPE (Pro-Pro-Glu) protein families of Mycobacterium tuberculosis …

Characterizing host immune responses to molecular targets of Mycobacterium tuberculosis
is essential to develop effective immunodiagnostics and better vaccines. We investigated the …

Bordetella pertussis adenylate cyclase (CyaA) toxoid is a powerful nonreplicative
immunization vector targeting dendritic cells, which has already been used successfully in …