A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation
CT Supuran - Bioorganic & Medicinal Chemistry Letters, 2023 - Elsevier
Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …
are presented, with an emphasis on the deciphering of the activation mechanism, the …
An overview of novel antimicrobial carbonic anhydrase inhibitors
CT Supuran - Expert Opinion on Therapeutic Targets, 2023 - Taylor & Francis
Introduction Four different genetic families of the enzyme carbonic anhydrase (CA, EC 4.2.
1.1) are present in bacteria, α-, β-, γ-and ι-CAs. They play relevant functions related to CO2 …
1.1) are present in bacteria, α-, β-, γ-and ι-CAs. They play relevant functions related to CO2 …
Multi-and poly-pharmacology of carbonic anhydrase inhibitors
CT Supuran - Pharmacological Reviews, 2024 - Elsevier
Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …
Development of Penicillin-Based Carbonic Anhydrase Inhibitors Targeting Multidrug-Resistant Neisseria gonorrhoeae
The development of antibacterial drugs with new mechanisms of action is crucial in
combating the rise of antibiotic-resistant infections. Bacterial carbonic anhydrases (CAs, EC …
combating the rise of antibiotic-resistant infections. Bacterial carbonic anhydrases (CAs, EC …
Management of Neisseria gonorrhoeae infection: from drug resistance to drug repurposing
L Pisano, S Giovannuzzi… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Neisseria gonorrhoeae is a common sexually transmitted disease connected
with extensive drug resistance to many antibiotics. Presently, only expanded spectrum …
with extensive drug resistance to many antibiotics. Presently, only expanded spectrum …
Five-membered heterocyclic sulfonamides as carbonic anhydrase inhibitors
The development of heterocyclic derivatives has progressed considerably over the past
decades, and many new carbonic anhydrase inhibitors (CAIs) fall into this field. In particular …
decades, and many new carbonic anhydrase inhibitors (CAIs) fall into this field. In particular …
Drug interactions of carbonic anhydrase inhibitors and activators
CT Supuran - Expert Opinion on Drug Metabolism & Toxicology, 2024 - Taylor & Francis
ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) have been established
drug targets for decades, with their inhibitors and activators possessing relevant …
drug targets for decades, with their inhibitors and activators possessing relevant …
Challenges for develo** bacterial CA inhibitors as novel antibiotics
CT Supuran - Enzymes, 2024 - books.google.com
Challenges for develo** bacterial CA inhibitors as novel antibiotics Page 400 CHAPTER
THIRTEEN Challenges for develo** bacterial CA inhibitors as novel antibiotics Claudiu T …
THIRTEEN Challenges for develo** bacterial CA inhibitors as novel antibiotics Claudiu T …
Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae
Drug-resistant gonorrhea is caused by the bacterial pathogen Neisseria gonorrhoeae, for
which there is no recommended oral treatment. We have demonstrated that the FDA …
which there is no recommended oral treatment. We have demonstrated that the FDA …
Inhibition studies with simple and complex (in)organic anions of the γ-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri, MscCAγ
The γ-carbonic anhydrase (CA, EC 4.2. 1.1) from the pathogenic bacterium,
Mammaliicoccus (Staphylococcus) sciuri (MscCAγ) was recently cloned and purified by our …
Mammaliicoccus (Staphylococcus) sciuri (MscCAγ) was recently cloned and purified by our …