Metallodrugs are unique: Opportunities and challenges of discovery and development
EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …
are not accessible to purely organic compounds. At least 10 metals are essential for human …
Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses
The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …
complexes could play a more significant role in human cancer therapy. However, targeting …
Stimuli-responsive therapeutic metallodrugs
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …
metal-based drugs for several decades, whereas problems such as drug-resistance and …
Organometallic anticancer compounds
The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …
The medicinal chemistry of ferrocene and its derivatives
Ferrocene derivatives have attracted significant interest as anticancer, antibacterial,
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …
New trends for metal complexes with anticancer activity
PCA Bruijnincx, PJ Sadler - Current opinion in chemical biology, 2008 - Elsevier
Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design
of new drugs. This has, for instance, led to the clinical application of chemotherapeutic …
of new drugs. This has, for instance, led to the clinical application of chemotherapeutic …
Ferrocifen type anti cancer drugs
Despite current developments in therapeutics focusing on biotechnologically-oriented
species, the unflagging utility of small molecules or peptides in medicine is still producing …
species, the unflagging utility of small molecules or peptides in medicine is still producing …
Why is ferrocene so exceptional?
D Astruc - European Journal of Inorganic Chemistry, 2017 - Wiley Online Library
The appearance of ferrocene in the middle of the 20th century has revolutionized
organometallic chemistry and is now providing applications in areas as varied and …
organometallic chemistry and is now providing applications in areas as varied and …
Has ferrocene really delivered its role in accentuating the bioactivity of organic scaffolds?
Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …
Bioorganometallic chemistry—from teaching paradigms to medicinal applications
In undergraduate level organometallic chemistry courses students are usually taught that
organometallic compounds are toxic and unstable in air and water. While this is true of many …
organometallic compounds are toxic and unstable in air and water. While this is true of many …