Metallodrugs are unique: Opportunities and challenges of discovery and development

EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses

K Peng, Y Zheng, W **a, ZW Mao - Chemical Society Reviews, 2023 - pubs.rsc.org
The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …

Stimuli-responsive therapeutic metallodrugs

X Wang, X Wang, S **, N Muhammad, Z Guo - Chemical reviews, 2018 - ACS Publications
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …

Organometallic anticancer compounds

G Gasser, I Ott, N Metzler-Nolte - Journal of medicinal chemistry, 2011 - ACS Publications
The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …

The medicinal chemistry of ferrocene and its derivatives

M Patra, G Gasser - Nature Reviews Chemistry, 2017 - nature.com
Ferrocene derivatives have attracted significant interest as anticancer, antibacterial,
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …

New trends for metal complexes with anticancer activity

PCA Bruijnincx, PJ Sadler - Current opinion in chemical biology, 2008 - Elsevier
Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design
of new drugs. This has, for instance, led to the clinical application of chemotherapeutic …

Ferrocifen type anti cancer drugs

G Jaouen, A Vessières, S Top - Chemical Society Reviews, 2015 - pubs.rsc.org
Despite current developments in therapeutics focusing on biotechnologically-oriented
species, the unflagging utility of small molecules or peptides in medicine is still producing …

Why is ferrocene so exceptional?

D Astruc - European Journal of Inorganic Chemistry, 2017 - Wiley Online Library
The appearance of ferrocene in the middle of the 20th century has revolutionized
organometallic chemistry and is now providing applications in areas as varied and …

Has ferrocene really delivered its role in accentuating the bioactivity of organic scaffolds?

B Sharma, V Kumar - Journal of medicinal chemistry, 2021 - ACS Publications
Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

CG Hartinger, PJ Dyson - Chemical Society Reviews, 2009 - pubs.rsc.org
In undergraduate level organometallic chemistry courses students are usually taught that
organometallic compounds are toxic and unstable in air and water. While this is true of many …