[HTML][HTML] Atherosclerosis: recent developments

JLM Björkegren, AJ Lusis - Cell, 2022‏ - cell.com
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …

A global view of the interplay between non-alcoholic fatty liver disease and diabetes

N Stefan, K Cusi - The lancet Diabetes & endocrinology, 2022‏ - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, much like other non-
communicable diseases (NCDs), such as cancer, obesity, diabetes, and cardiovascular …

Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

L Ottensmann, R Tabassum, SE Ruotsalainen… - Nature …, 2023‏ - nature.com
The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations

C Tcheandjieu, X Zhu, AT Hilliard, SL Clarke… - Nature medicine, 2022‏ - nature.com
We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with …

The complex link between NAFLD and type 2 diabetes mellitus—mechanisms and treatments

G Targher, KE Corey, CD Byrne… - … reviews Gastroenterology & …, 2021‏ - nature.com
Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide.
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …

Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis

A Mantovani, A Csermely, G Petracca… - The lancet …, 2021‏ - thelancet.com
Background Studies have reported a significant association between non-alcoholic fatty liver
disease (NAFLD) and increased incidence of cardiovascular disease (CVD). However, the …

[HTML][HTML] Metabolic-associated fatty liver disease and lipoprotein metabolism

J Heeren, L Scheja - Molecular metabolism, 2021‏ - Elsevier
Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

MAFLD: a multisystem disease

RM Pipitone, C Ciccioli, G Infantino… - Therapeutic …, 2023‏ - journals.sagepub.com
Nonalcoholic fatty liver disease (NAFLD), affecting about 25% of general population and
more than 50% of dysmetabolic patients, is an emerging cause of chronic liver disease and …

Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia

J Boren, MR Taskinen, E Björnson… - Nature Reviews …, 2022‏ - nature.com
Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their
cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only …

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

TP Fidler, C Xue, M Yalcinkaya, B Hardaway… - Nature, 2021‏ - nature.com
Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic
mutations that endow a proliferative advantage to haematopoietic cells. Clonal …