The addition of a radical to a heteroaromatic base is commonly referred to as a Minsici
reaction. Such reactions constitute a broad-set of selective CH-functionalization processes …

Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

The incidence of tuberculosis has been increasing substantially on a worldwide basis over
the past decade, but no tuberculosis-specific drugs have been discovered in 40 years. We …

There is an urgent need for the discovery and development of new antitubercular agents that
target new biochemical pathways and treat drug resistant forms of the disease. One …

Drugs for treating tuberculosis (TB) have been available for over half a century, and yet the
incidence of disease worldwide continues to rise year by year. In 2002, the last year for …

The increasing drug resistance of M ycobacterium tuberculosis to the currently used drugs
and HIV coinfection has caused alarm in the international scientific community …

Tuberculosis (TB) is one of the most devastating diseases primarily due to several decades
of neglect and presents a global health threat of escalating proportions. TB is second …

Structural optimization of the previously identified 4-(adamantan-1-yl)-2-
quinolinecarbohydrazide (AQCH, MIC= 6.25 μg/mL, 99% inhibition, Mycobacterium …

We describe in vitro anti-Mycobacterium tuberculosis activities of ring-substituted-1H-
imidazole-4-carboxylic acid derivatives (1–6), and 3-(2-alkyl-1H-imidazol-4-yl)-propionic …

Tuberculosis is a leading infectious cause of death worldwide. Because of the concern of the
resistance to most of the commonly used drugs displayed by the considered mycobacteria …