The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …
chromatin modification that critically contributes to the regulation of genome integrity …
Mechanisms that regulate the activities of TET proteins
K Joshi, S Liu, P Breslin SJ, J Zhang - Cellular and Molecular Life Sciences, 2022 - Springer
The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
Genomic profiling for clinical decision making in lymphoid neoplasms
With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
sequencing technologies, the genomic features of most lymphoid neoplasms have been …
Age-related clonal hematopoiesis associated with adverse outcomes
Background The incidence of hematologic cancers increases with age. These cancers are
associated with recurrent somatic mutations in specific genes. We hypothesized that such …
associated with recurrent somatic mutations in specific genes. We hypothesized that such …
TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis
Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal
hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined …
hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined …
Regulatory mechanisms of epigenetic miRNA relationships in human cancer and potential as therapeutic targets
Simple Summary By the virtue of targeting multiple genes, a microRNA (miRNA) can infer
variable consequences on tumorigenesis by appearing as both a tumour suppressor and …
variable consequences on tumorigenesis by appearing as both a tumour suppressor and …
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis
DNA methylation is tightly regulated throughout mammalian development, and altered DNA
methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase …
methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase …
The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases
Abstract Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation,
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …
deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event …
TET proteins and the control of cytosine demethylation in cancer
L Scourzic, E Mouly, OA Bernard - Genome medicine, 2015 - Springer
The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …
TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation, and promotes B-cell lymphomagenesis
TET2 somatic mutations occur in∼ 10% of diffuse large B-cell lymphomas (DLBCL) but are
of unknown significance. Herein, we show that TET2 is required for the humoral immune …
of unknown significance. Herein, we show that TET2 is required for the humoral immune …