Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Significance: Keratinocytes, a major cellular component of the epidermis, are responsible for
restoring the epidermis after injury through a process termed epithelialization. This review …

Stem cells support lifelong maintenance of adult organs, but their specific roles during injury
are poorly understood. Here we demonstrate that Lgr6 marks a regionally restricted …

Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement
membrane zone. COL17 deficiency results in premature hair aging phenotypes and in …

Heat shock proteins (HSPs), a large group of highly evolutionary conserved proteins, are
considered to be main elements of the cellular proteoprotection system. HSPs are encoded …

The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous
gland (SG), and interfollicular epidermis (IFE) of murine skin are still poorly understood. In …

The interfollicular epidermis (IFE) forms a water-tight barrier that is often disrupted in
inflammatory skin diseases. During homeostasis, the IFE is replenished by stem cells in the …

The importance of skin to survival, and the devastating physical and psychological
consequences of scarring following reparative healing of extensive or difficult to heal human …

Lineage tracing involves labeling cells to track their subsequent behavior within the normal
tissue environment. The advent of genetic lineage tracing and cell proliferation assays …

The epidermis is maintained by epidermal stem cells (ESC s) that reside in distinct niches
and contribute to homeostasis and wound closure. Keratinocytes at the nonhealing edges of …