Background Anaesthetic drugs act at sites within the brain that undergo profound changes
during typical ageing. We postulated that anaesthesia-induced brain dynamics observed in …

Remembering experiences that lead to reward is essential for survival. The hippocampus is
required for forming and storing memories of events and places, but the mechanisms that …

Concept cells in the human hippocampus encode the meaning conveyed by stimuli over
their perceptual aspects. Here we investigate whether analogous cells in the macaque can …

To elucidate how gaze informs the construction of mental space during wayfinding in visual
species like primates, we jointly examined navigation behavior, visual exploration, and …

Navigation abilities decline with age, partly due to deficits in numerous component
processes. Impaired switching between these various processes (ie, switching navigational …

Theta rhythms temporally coordinate sequences of hippocampal place cell ensembles
during active behaviors, while sharp wave-ripples coordinate place cell sequences during …

Background Physical activity is considered as a major component of a healthy lifestyle.
However, few studies have examined the relationships between the spatial accessibility to …

Prefrontal (PFC) and hippocampal (HPC) sequences of neuronal firing modulated by theta
rhythms could represent upcoming choices during spatial memory-guided decision-making …

Recording single-neuron activity from a specific brain region across multiple trials in
response to the same stimulus or execution of the same behavioral task is a common …

Observability of a dynamical system requires an understanding of its state—the collective
values of its variables. However, existing techniques are too limited to measure all but a …