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[HTML][HTML] Cellular therapies in older adults with hematological malignancies: A case-based, state-of-the-art review
Cellular therapies, including autologous stem cell transplant (ASCT), allogeneic
hematopoietic cell transplantation (alloHCT), and chimeric antigen receptor-(CAR-) T cell …
hematopoietic cell transplantation (alloHCT), and chimeric antigen receptor-(CAR-) T cell …
A roadmap towards improving outcomes in multiple myeloma
M Mohty, T Facon, F Malard, JL Harousseau - Blood Cancer Journal, 2024 - nature.com
Multiple myeloma (MM) is a chronic hematologic malignancy that remains incurable,
because most patients eventually relapse or become refractory to current treatments. MM is …
because most patients eventually relapse or become refractory to current treatments. MM is …
Cancer-specific mortality in multiple myeloma: a population-based retrospective cohort study
A McCurdy, H Seow, GP Pond, A Gayowsky… - …, 2023 - pmc.ncbi.nlm.nih.gov
Survival has improved in patients diagnosed with multiple myeloma (MM) over the last two
decades; however, there remains a paucity of data on the causes of death in MM patients …
decades; however, there remains a paucity of data on the causes of death in MM patients …
Personalized treatment of multiple myeloma in frail patients
JJ Lipof, N Abdallah, B Lipe - Current Oncology Reports, 2024 - Springer
Abstract Purpose of Review As the treatment landscape for multiple myeloma (MM)
continues to expand at a rapid pace, management of older adults and frail patients becomes …
continues to expand at a rapid pace, management of older adults and frail patients becomes …
Hematological malignancies in older patients: Focus on the potential role of a geriatric assessment management
S Caserta, G Cancemi, S Loreta, A Allegra, F Stagno - Diagnostics, 2024 - mdpi.com
Geriatric assessment management is a multidimensional tool used to evaluate prognosis for
clinical outcomes and targets for interventions in older adults with cancer receiving …
clinical outcomes and targets for interventions in older adults with cancer receiving …
International myeloma working group immunotherapy committee recommendation on sequencing immunotherapy for treatment of multiple myeloma
T-cell redirecting therapy (TCRT), specifically chimeric antigen receptor T-cell therapy (CAR
T-cells) and bispecific T-cell engagers (TCEs) represent a remarkable advance in the …
T-cells) and bispecific T-cell engagers (TCEs) represent a remarkable advance in the …
[HTML][HTML] Recommendations for the effective use of T-cell–redirecting therapies: A Canadian consensus statement
G Lancman, K Song, D White, T Crosbie… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Background T-cell–redirecting therapies, such as bispecific antibodies and chimeric antigen
receptor T-cells, exploit the cytotoxic capabilities of the immune system to destroy cells …
receptor T-cells, exploit the cytotoxic capabilities of the immune system to destroy cells …
Prevalence of geriatric impairments and frailty categorization among real-world patients with multiple myeloma: a prospective cohort study (MFRAIL)
I Haider, DP Leong, M Louzada, A McCurdy… - Leukemia & …, 2024 - Taylor & Francis
There is limited knowledge regarding the prevalence of geriatric impairments and frailty
among patients with multiple myeloma (MM) in a real-world setting. This study evaluated the …
among patients with multiple myeloma (MM) in a real-world setting. This study evaluated the …
MRD negativity: considerations for older adults with multiple myeloma
Minimal (or measurable) residual disease (MRD) negativity has emerged as one of the most
important prognostic tools in multiple myeloma (MM) and is associated with significant …
important prognostic tools in multiple myeloma (MM) and is associated with significant …
LTe2 induces cell apoptosis in multiple myeloma by suppressing AKT phosphorylation at Thr308 and Ser473
Y Zhang, J Qian, M Jiang, S Yang, L Zhou… - Frontiers in …, 2023 - frontiersin.org
Multiple myeloma (MM) is a highly heterogeneous hematological malignancy originating
from B lymphocytes, with a high recurrence rate primarily due to drug resistance. 2-((1H …
from B lymphocytes, with a high recurrence rate primarily due to drug resistance. 2-((1H …