Homologous recombination (HR) is a highly conserved DNA repair mechanism that protects
cells from exogenous and endogenous DNA damage. Breast cancer 1 (BRCA1) and breast …

Missense variants in the BRCA 2 gene are routinely detected during clinical screening for
pathogenic mutations in patients with a family history of breast and ovarian cancer. These …

Importance The link betweenBRCAmutations and uterine cancer is unclear. Therefore,
although risk-reducing sal**o-oophorectomy (RRSO) is standard treatment among …

Preoperative therapy provides an advantage for clinical drug assessment, as it involves yet
untreated patients and facilitates access to the post-treatment biological material. Testing for …

The purpose of our study was to establish the frequency and distribution of the four most
common BRCA1 mutations in Polish general population and in a series of breast cancer …

Objectives: The purpose of this study was to evaluate the level of expression of the BRCA1
and BRCA2 proteins in sporadic breast cancer cases to determine the functional role of …

BRCA1 dysfunction may occur by different mechanisms that are rarely evaluated
concomitantly. We aimed to analyze BRCA1 germline mutations, loss of heterozygosity …

The Opinion article we wrote (BRCA1 and BRCA2: different roles in a common pathway of
genome protection. Nature Rev. Cancer 12, 68–78 (2012)) 1 on the functions of BRCA1 and …

Disseminated tumor cells (DTC) in the bone marrow (BM) are present in about 35% of
ovarian cancers before surgery and after chemotherapy and are associated with worse …

BRCA1 is a major gatekeeper of genomic stability. Acting in multiple central processes like
double-strand break repair, centrosome replication, and checkpoint control, BRCA1 …