Therapeutic strategies targeting connexins
The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …
Connexins in cardiovascular and neurovascular health and disease: pharmacological implications
Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
hemichannels and as intercellular gap junction channels that directly connect cells. In the …
Inhibitors of connexin and pannexin channels as potential therapeutics
J Willebrords, M Maes, SC Yanguas… - Pharmacology & …, 2017 - Elsevier
While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …
cells, connexin hemichannels provide communication between the cytosol and the …
Intercellular communication in the heart: therapeutic opportunities for cardiac ischemia
The maintenance of tissue, organ, and organism homeostasis relies on an intricate network
of players and mechanisms that assist in the different forms of cell–cell communication …
of players and mechanisms that assist in the different forms of cell–cell communication …
Glial connexins and pannexins in the healthy and diseased brain
C Giaume, CC Naus, JC Sáez… - Physiological …, 2021 - journals.physiology.org
Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …
main cell population in the brain, dynamically interact with neurons and thus impact their …
Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve …
RS Tonkin, C Bowles, CJ Perera, BA Keating… - Experimental …, 2018 - Elsevier
Abstract Connexin43 (Cx43) hemichannels in spinal cord astrocytes are implicated in the
maintenance of neuropathic pain following peripheral nerve injury. Peptide5 is a Cx43 …
maintenance of neuropathic pain following peripheral nerve injury. Peptide5 is a Cx43 …
The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release
Background Connexin43 hemichannels have been implicated in many inflammatory
diseases including diabetic retinopathy (DR). Particularly, hemichannel-mediated ATP …
diseases including diabetic retinopathy (DR). Particularly, hemichannel-mediated ATP …
[HTML][HTML] Connexin hemichannel block using orally delivered tonabersat improves outcomes in animal models of retinal disease
Increased Connexin43 hemichannel opening is associated with inflammasome pathway
activation and inflammation in a range of pathologies including ocular disorders, such as …
activation and inflammation in a range of pathologies including ocular disorders, such as …
Therapeutic targeting of connexin channels: new views and challenges
Connexins, in particular connexin 43 (Cx43), function as gap junction channels (GJCs) and
hemichannels (HCs). Only recently, specific tools have been developed to study their …
hemichannels (HCs). Only recently, specific tools have been developed to study their …
Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury
E Roger, CE Chadjichristos, P Kavvadas… - Cell Communication and …, 2023 - Springer
Background Without a viable cure, chronic kidney disease is a global health concern.
Inflammatory damage in and around the renal tubules dictates disease severity and is …
Inflammatory damage in and around the renal tubules dictates disease severity and is …