There is an increasing recognition of clinical overlap in patients presenting with epilepsy
and autism spectrum disorder (ASD), and a great deal of new information regarding the …

The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

Individuals with mutations in forkhead box G1 (FOXG1) belong to a distinct clinical entity,
termed “FOXG1-related encephalopathy”. There are two clinical phenotypes/syndromes …

Probing histone modifications at a single-cell level in thousands of cells has been enabled
by technologies such as single-cell CUT&Tag. Here we describe nano-CUT&Tag (nano-CT) …

Presbycusis is the cumulative effect of aging on hearing. Recent studies have shown that
common mitochondrial gene deletions are closely related to deafness caused by …

Inflammation is a self-defense response to protect individuals from infection and tissue
damage, but excessive or persistent inflammation can have adverse effects on cell survival …

Quercetin, a naturally occurring flavonoid, has been reported to exert antidepressant effects,
however, the underlying mechanisms are still uncertain. Recent studies have demonstrated …

The role of intracellular transcriptional/post-translational feedback loops (TTFL) within the
circadian pacemaker of the suprachiasmatic nucleus (SCN) is well established. In contrast …

Foxg1 is one of the forkhead box genes that are involved in morphogenesis, cell fate
determination, and proliferation, and Foxg1 was previously reported to be required for …

Forkhead Box G1 (FOXG1) is a member of the Forkhead family of genes with non-redundant
roles in brain development, where alteration of this gene's expression significantly affects …