Mesenchymal cell contributions to the stem cell niche

Y Kfoury, DT Scadden - Cell stem cell, 2015 - cell.com
Mesenchymal stromal cells (MSCs) are heterogeneous and primitive cells discovered first in
the bone marrow (BM). They have putative roles in maintaining tissue homeostasis and are …

Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue

S Golpanian, A Wolf, KE Hatzistergos… - Physiological …, 2016 - journals.physiology.org
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …

Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration

TH Ambrosi, A Scialdone, A Graja, S Gohlke, AM Jank… - Cell stem cell, 2017 - cell.com
Aging and obesity induce ectopic adipocyte accumulation in bone marrow cavities. This
process is thought to impair osteogenic and hematopoietic regeneration. Here we specify …

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

S Méndez-Ferrer, TV Michurina, F Ferraro… - nature, 2010 - nature.com
The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone
marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells …

The liver–brain–gut neural arc maintains the Treg cell niche in the gut

T Teratani, Y Mikami, N Nakamoto, T Suzuki, Y Harada… - Nature, 2020 - nature.com
Recent clinical and experimental evidence has evoked the concept of the gut–brain axis to
explain mutual interactions between the central nervous system and gut microbiota that are …

PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

S Pinho, J Lacombe, M Hanoun, T Mizoguchi… - Journal of Experimental …, 2013 - rupress.org
The intermediate filament protein Nestin labels populations of stem/progenitor cells,
including self-renewing mesenchymal stem cells (MSCs), a major constituent of the …

Unique multipotent cells in adult human mesenchymal cell populations

Y Kuroda, M Kitada, S Wakao… - Proceedings of the …, 2010 - National Acad Sciences
We found adult human stem cells that can generate, from a single cell, cells with the
characteristics of the three germ layers. The cells are stress-tolerant and can be isolated …

Bone marrow mesenchymal stem cells: historical overview and concepts

P Charbord - Human gene therapy, 2010 - liebertpub.com
This review describes the historical emergence of the concept of bone marrow
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …

Neuroblastoma origin and therapeutic targets for immunotherapy

IV Kholodenko, DV Kalinovsky… - Journal of …, 2018 - Wiley Online Library
Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique
features of this type of cancer frequently hamper the process of determining clinical …

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

N Asada, M Takase, J Nakamura… - The Journal of …, 2011 - Am Soc Clin Investig
In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia.
Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is …