Mesenchymal cell contributions to the stem cell niche
Mesenchymal stromal cells (MSCs) are heterogeneous and primitive cells discovered first in
the bone marrow (BM). They have putative roles in maintaining tissue homeostasis and are …
the bone marrow (BM). They have putative roles in maintaining tissue homeostasis and are …
Rebuilding the damaged heart: mesenchymal stem cells, cell-based therapy, and engineered heart tissue
S Golpanian, A Wolf, KE Hatzistergos… - Physiological …, 2016 - journals.physiology.org
Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …
Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration
Aging and obesity induce ectopic adipocyte accumulation in bone marrow cavities. This
process is thought to impair osteogenic and hematopoietic regeneration. Here we specify …
process is thought to impair osteogenic and hematopoietic regeneration. Here we specify …
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone
marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells …
marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells …
The liver–brain–gut neural arc maintains the Treg cell niche in the gut
Recent clinical and experimental evidence has evoked the concept of the gut–brain axis to
explain mutual interactions between the central nervous system and gut microbiota that are …
explain mutual interactions between the central nervous system and gut microbiota that are …
PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion
The intermediate filament protein Nestin labels populations of stem/progenitor cells,
including self-renewing mesenchymal stem cells (MSCs), a major constituent of the …
including self-renewing mesenchymal stem cells (MSCs), a major constituent of the …
Unique multipotent cells in adult human mesenchymal cell populations
Y Kuroda, M Kitada, S Wakao… - Proceedings of the …, 2010 - National Acad Sciences
We found adult human stem cells that can generate, from a single cell, cells with the
characteristics of the three germ layers. The cells are stress-tolerant and can be isolated …
characteristics of the three germ layers. The cells are stress-tolerant and can be isolated …
Bone marrow mesenchymal stem cells: historical overview and concepts
P Charbord - Human gene therapy, 2010 - liebertpub.com
This review describes the historical emergence of the concept of bone marrow
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …
Neuroblastoma origin and therapeutic targets for immunotherapy
IV Kholodenko, DV Kalinovsky… - Journal of …, 2018 - Wiley Online Library
Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique
features of this type of cancer frequently hamper the process of determining clinical …
features of this type of cancer frequently hamper the process of determining clinical …
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice
N Asada, M Takase, J Nakamura… - The Journal of …, 2011 - Am Soc Clin Investig
In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia.
Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is …
Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is …