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Extracellular vesicles as regulators of the extracellular matrix
NJ Patel, A Ashraf, EJ Chung - Bioengineering, 2023 - mdpi.com
Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the
extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids …
extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids …
CRISPR-Cas9 delivery strategies with engineered extracellular vesicles
Therapeutic genome editing has the potential to cure diseases by directly correcting genetic
mutations in tissues and cells. Recent progress in the CRISPR-Cas9 systems has led to …
mutations in tissues and cells. Recent progress in the CRISPR-Cas9 systems has led to …
Engineering a tunable micropattern‐array assay to sort single extracellular vesicles and particles to detect RNA and protein in situ
The molecular heterogeneity of extracellular vesicles (EVs) and the co‐isolation of
physically similar particles, such as lipoproteins (LPs), confounds and limits the sensitivity of …
physically similar particles, such as lipoproteins (LPs), confounds and limits the sensitivity of …
Circulating non-coding RNAs in chronic kidney disease and its complications
AJ van Zonneveld, Q Zhao, JI Rotmans… - Nature Reviews …, 2023 - nature.com
Post-transcriptional regulation by non-coding RNAs (ncRNAs) can modulate the expression
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …
Extracellular vesicles as carriers of mRNA: Opportunities and challenges in diagnosis and treatment
Extracellular vesicles (EVs) are produced by all cells in the body. These biological
nanoparticles facilitate cellular communication through the transport of diverse cargoes …
nanoparticles facilitate cellular communication through the transport of diverse cargoes …
Standardization approaches for extracellular vesicle loading with oligonucleotides and biologics
J Roerig, M Schulz‐Siegmund - Small, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are widely recognized for their potential as drug delivery
systems. EVs are membranous nanoparticles shed from cells. Among their natural features …
systems. EVs are membranous nanoparticles shed from cells. Among their natural features …
Versatility of mesenchymal stem cell-derived extracellular vesicles in tissue repair and regenerative applications
Mesenchymal stem/stromal cells (MSCs) are multipotent somatic cells that have been widely
explored in the field of regenerative medicine. MSCs possess the ability to secrete soluble …
explored in the field of regenerative medicine. MSCs possess the ability to secrete soluble …
Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages
P Pantazi, T Clements, M Venø… - Journal of …, 2022 - Wiley Online Library
Macrophages are important antigen presenting cells which can release extracellular
vesicles (EVs) carrying functional cargo including non‐coding RNAs. Macrophages can be …
vesicles (EVs) carrying functional cargo including non‐coding RNAs. Macrophages can be …
Challenges associated with using extracellular vesicles as biomarkers in neurodegenerative disease
Y Couch - Expert Review of Molecular Diagnostics, 2023 - Taylor & Francis
Introduction The hunt for new biomarkers–for the diagnosis of subcategories of disease, or
for the monitoring of the efficacy of novel therapeutics–is an increasingly relevant challenge …
for the monitoring of the efficacy of novel therapeutics–is an increasingly relevant challenge …
[HTML][HTML] New insights into the potential effects of PET microplastics on organisms via extracellular vesicle-mediated communication
Plastics have become an integral part of our daily lives. In the environment, plastics break
down into small pieces (< 5 mm) that are referred to as microplastics. Microplastics are …
down into small pieces (< 5 mm) that are referred to as microplastics. Microplastics are …