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Ischemia, immunosuppression and infection—tackling the predicaments of post-stroke complications
The incidence of stroke has risen over the past decade and will continue to be one of the
leading causes of death and disability worldwide. While a large portion of immediate death …
leading causes of death and disability worldwide. While a large portion of immediate death …
Thrombosis, neuroinflammation, and poststroke infection: the multifaceted role of neutrophils in stroke
J Ruhnau, J Schulze, A Dressel… - Journal of immunology …, 2017 - Wiley Online Library
Immune cells can significantly predict and affect the clinical outcome of stroke. In particular,
the neutrophil‐to‐lymphocyte ratio was shown to predict hemorrhagic transformation and the …
the neutrophil‐to‐lymphocyte ratio was shown to predict hemorrhagic transformation and the …
A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion
Background Microglia cells continuously survey the healthy brain in a ramified morphology
and, in response to injury, undergo progressive morphological and functional changes that …
and, in response to injury, undergo progressive morphological and functional changes that …
Formyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in …
Background—Platelet activation at sites of vascular injury is essential for hemostasis, but it is
also a major pathomechanism underlying ischemic injury. Because anti-inflammatory …
also a major pathomechanism underlying ischemic injury. Because anti-inflammatory …
Can quantifying morphology and TMEM119 expression distinguish between microglia and infiltrating macrophages after ischemic stroke and reperfusion in male and …
KF Young, R Gardner, V Sariana, SA Whitman… - Journal of …, 2021 - Springer
Background Ischemic stroke is an acquired brain injury with gender-dependent outcomes. A
persistent obstacle in understanding the sex-specific neuroinflammatory contributions to …
persistent obstacle in understanding the sex-specific neuroinflammatory contributions to …
AQP4 knockout aggravates ischemia/reperfusion injury in mice
XN Zeng, LL **e, R Liang, XL Sun… - CNS neuroscience & …, 2012 - Wiley Online Library
SUMMARY Background and Purpose: The glial water channel aquaporin‐4 (AQP4) has
been shown to be involved in a wide range of brain disorders. Although its important role in …
been shown to be involved in a wide range of brain disorders. Although its important role in …
Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice
Background During the acute stroke phase, neutrophils from the peripheral blood are first to
arrive in the ischemic brain, which then attracts other immune cells that exacerbate …
arrive in the ischemic brain, which then attracts other immune cells that exacerbate …
Abatement of neurobehavioral and neurochemical dysfunctions in cerebral ischemia/reperfusion injury by Tetrapleura tetraptera fruit extract
Abstract Ethnopharmacological relevance Tetrapleura tetraptera Taub.(family Fabaceae), is
generally found in the lowland forest of tropical Africa. Its leaves and fruits are traditionally …
generally found in the lowland forest of tropical Africa. Its leaves and fruits are traditionally …
A novel approach to treatment of thromboembolic stroke in mice: Redirecting neutrophils toward a peripherally implanted CXCL1-soaked sponge
SM Stamatovic, CM Phillips, RF Keep… - Experimental …, 2020 - Elsevier
Neutrophils are considered key participants in post-ischemic stroke inflammation. They are
the first white blood cells to arrive in ischemic brain and their presence in the brain tissue …
the first white blood cells to arrive in ischemic brain and their presence in the brain tissue …
Dodecafluoropentane emulsion as an oxygen therapeutic
JLH Johnson, E Unger - Artificial Cells, Nanomedicine, and …, 2024 - Taylor & Francis
Dodecafluoropentane emulsion (DDFPe) is a fluorocarbon (FC) under clinical development
as an oxygen therapeutic and is regulated as a blood substitute. Compared to all the prior …
as an oxygen therapeutic and is regulated as a blood substitute. Compared to all the prior …