Ischemia, immunosuppression and infection—tackling the predicaments of post-stroke complications

R Shim, CHY Wong - International journal of molecular sciences, 2016 - mdpi.com
The incidence of stroke has risen over the past decade and will continue to be one of the
leading causes of death and disability worldwide. While a large portion of immediate death …

Thrombosis, neuroinflammation, and poststroke infection: the multifaceted role of neutrophils in stroke

J Ruhnau, J Schulze, A Dressel… - Journal of immunology …, 2017 - Wiley Online Library
Immune cells can significantly predict and affect the clinical outcome of stroke. In particular,
the neutrophil‐to‐lymphocyte ratio was shown to predict hemorrhagic transformation and the …

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

HW Morrison, JA Filosa - Journal of neuroinflammation, 2013 - Springer
Background Microglia cells continuously survey the healthy brain in a ramified morphology
and, in response to injury, undergo progressive morphological and functional changes that …

Formyl-Peptide Receptor 2/3/Lipoxin A4 Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral Inflammation: Impact for Therapy in …

SA Vital, F Becker, PM Holloway, J Russell, M Perretti… - Circulation, 2016 - ahajournals.org
Background—Platelet activation at sites of vascular injury is essential for hemostasis, but it is
also a major pathomechanism underlying ischemic injury. Because anti-inflammatory …

Can quantifying morphology and TMEM119 expression distinguish between microglia and infiltrating macrophages after ischemic stroke and reperfusion in male and …

KF Young, R Gardner, V Sariana, SA Whitman… - Journal of …, 2021 - Springer
Background Ischemic stroke is an acquired brain injury with gender-dependent outcomes. A
persistent obstacle in understanding the sex-specific neuroinflammatory contributions to …

AQP4 knockout aggravates ischemia/reperfusion injury in mice

XN Zeng, LL **e, R Liang, XL Sun… - CNS neuroscience & …, 2012 - Wiley Online Library
SUMMARY Background and Purpose: The glial water channel aquaporin‐4 (AQP4) has
been shown to be involved in a wide range of brain disorders. Although its important role in …

Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice

Y Wang, H **, W Wang, F Wang, H Zhao - Journal of neuroinflammation, 2019 - Springer
Background During the acute stroke phase, neutrophils from the peripheral blood are first to
arrive in the ischemic brain, which then attracts other immune cells that exacerbate …

Abatement of neurobehavioral and neurochemical dysfunctions in cerebral ischemia/reperfusion injury by Tetrapleura tetraptera fruit extract

IO Saliu, ZA Amoo, MF Khan, MT Olaleye… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Tetrapleura tetraptera Taub.(family Fabaceae), is
generally found in the lowland forest of tropical Africa. Its leaves and fruits are traditionally …

A novel approach to treatment of thromboembolic stroke in mice: Redirecting neutrophils toward a peripherally implanted CXCL1-soaked sponge

SM Stamatovic, CM Phillips, RF Keep… - Experimental …, 2020 - Elsevier
Neutrophils are considered key participants in post-ischemic stroke inflammation. They are
the first white blood cells to arrive in ischemic brain and their presence in the brain tissue …

Dodecafluoropentane emulsion as an oxygen therapeutic

JLH Johnson, E Unger - Artificial Cells, Nanomedicine, and …, 2024 - Taylor & Francis
Dodecafluoropentane emulsion (DDFPe) is a fluorocarbon (FC) under clinical development
as an oxygen therapeutic and is regulated as a blood substitute. Compared to all the prior …