CRISPR/Cas9 therapeutics: progress and prospects

T Li, Y Yang, H Qi, W Cui, L Zhang, X Fu, X He… - Signal transduction and …, 2023 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases …

Stimuli-activatable nanomedicine meets cancer theranostics

H Li, Y Feng, Q Luo, Z Li, X Li, H Gan, Z Gu… - …, 2023 - pmc.ncbi.nlm.nih.gov
Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.
Upon exposure to endogenous/exogenous stimuli, the stimuli-activatable nanomedicine …

Metal–organic frameworks for biological applications

I Abánades Lázaro, X Chen, M Ding… - Nature Reviews …, 2024 - nature.com
Metal–organic frameworks (MOFs) have emerged as exciting potential new candidates for
application across nanomedicine, with the first example now in a phase II human clinical …

A bimetallic nanoplatform for STING activation and CRISPR/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune …

Y Huang, G Qin, TT Cui, C Zhao, J Ren, X Qu - Nature Communications, 2023 - nature.com
Lack of sufficient cytotoxic T lymphocytes (CD8+ T cells) infiltration and dysfunctional state of
CD8+ T cells are considered enormous obstacles to antitumor immunity. Herein, we …

Metal–organic frameworks for drug delivery: a design perspective

HD Lawson, SP Walton, C Chan - ACS applied materials & …, 2021 - ACS Publications
The use of metal–organic frameworks (MOFs) in biomedical applications has greatly
expanded over the past decade due to the precision tunability, high surface areas, and high …

Metal–organic framework-based enzyme biocomposites

W Liang, P Wied, F Carraro, CJ Sumby… - Chemical …, 2021 - ACS Publications
Because of their efficiency, selectivity, and environmental sustainability, there are significant
opportunities for enzymes in chemical synthesis and biotechnology. However, as the three …

The uptake of metal–organic frameworks: a journey into the cell

E Linnane, S Haddad, F Melle, Z Mei… - Chemical Society …, 2022 - pubs.rsc.org
The application of metal–organic frameworks (MOFs) in drug delivery has advanced rapidly
over the past decade, showing huge progress in the development of novel systems …

Metal–organic framework nanocarriers for drug delivery in biomedical applications

Y Sun, L Zheng, Y Yang, X Qian, T Fu, X Li, Z Yang… - Nano-Micro Letters, 2020 - Springer
Investigation of metal–organic frameworks (MOFs) for biomedical applications has attracted
much attention in recent years. MOFs are regarded as a promising class of nanocarriers for …

Stimuli-responsive drug delivery systems triggered by intracellular or subcellular microenvironments

T Sun, C Jiang - Advanced drug delivery reviews, 2023 - Elsevier
Drug delivery systems (DDS) triggered by local microenvironment represents the state-of-art
of nanomedicine design, where the triggering hallmarks at intracellular and subcellular …

Metal–organic framework-functionalized paper-based electrochemical biosensor for ultrasensitive exosome assay

X Liu, X Gao, L Yang, Y Zhao, F Li - Analytical chemistry, 2021 - ACS Publications
The exosome has emerged as a promising noninvasive biomarker for the early diagnosis of
cancer. Therefore, it is highly desirable to develop simple, inexpensive, and user-friendly …