Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

Highlights•Mutant K13-mediated artemisinin resistance involves reduced hemoglobin
endocytosis.•Artemisinin partial resistance has emerged in Africa.•Novel PfCRT mutations …

The artemisinin antimalarials are the cornerstone of current malaria treatment. The
development of artemisinin resistance in Plasmodium falciparum poses a major threat to …

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …

Enhancing the geographic coverage of surveillance for resistance will be key to ensure
prompt detection of emerging resistance in order to implement effective countermeasures …

The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the
Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria …

Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like
protein 13 (PfK13). Quiescence, a key aspect of resistance, may also be regulated by a yet …

Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now
threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we …