Tumor buster-where will the CAR-T cell therapy 'missile'go?

C Qu, H Zhang, H Cao, L Tang, H Mo, F Liu, L Zhang… - Molecular cancer, 2022 - Springer
Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing
technology represents a significant breakthrough in personalized immunotherapy for human …

[HTML][HTML] The dilemmas and possible solutions for CAR-T cell therapy application in solid tumors

L Wang, L Zhang, LC Dunmall, YY Wang, Z Fan… - Cancer Letters, 2024 - Elsevier
Chimeric antigen receptor T (CAR-T) cell therapy, as an adoptive immunotherapy, is playing
an increasingly important role in the treatment of malignant tumors. CAR-T cells are referred …

Updates in glioblastoma immunotherapy: an overview of the current clinical and translational scenario

A Bianconi, G Palmieri, G Aruta, M Monticelli, P Zeppa… - Biomedicines, 2023 - mdpi.com
Glioblastoma (GBM) is the most common and aggressive central nervous system tumor,
requiring multimodal management. Due to its malignant behavior and infiltrative growth …

Obstacles and co** strategies of CAR-T cell immunotherapy in solid tumors

L Miao, Z Zhang, Z Ren, F Tang, Y Li - Frontiers in Immunology, 2021 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell immunotherapy refers to an adoptive
immunotherapy that has rapidly developed in recent years. It is a novel type of treatment that …

Special chimeric antigen receptor (CAR) modifications of T cells: a review

L Miao, J Zhang, B Huang, Z Zhang, S Wang… - Frontiers in …, 2022 - frontiersin.org
Chimeric antigen receptor (CAR)-T cell therapy has become one of the hot topics in tumor
immunity research in recent years. Although CAR-T cell therapy is highly effective in treating …

New avenues for cancer immunotherapy: Cell-mediated drug delivery systems

H Zhang, A Grippin, M Sun, Y Ma, BYS Kim… - Journal of Controlled …, 2024 - Elsevier
Cancer research has become increasingly complex over the past few decades as
knowledge of the heterogeneity of cancer cells, their proliferative ability, and their tumor …

Insight into the progress in CAR-T cell therapy and combination with other therapies for Glioblastoma

T Liang, Y Song, L Gu, Y Wang… - International Journal of …, 2023 - Taylor & Francis
Glioblastoma (GBM) is the most common malignant primary brain cancer in adults. It is
always resistant to existing treatments, including surgical resection, postoperative …

Local immunotherapy of glioblastoma: A comprehensive review of the concept

M Sabahi, A Salehipour, MSY Bazl, N Rezaei… - Journal of …, 2023 - Elsevier
Despite advancements in standard treatments, the prognosis of Glioblastoma (GBM)
remains poor, prompting research for novel therapies. Immunotherapy is a promising …

Advanced strategies in improving the immunotherapeutic effect of CAR‐T cell therapy

M Wang, L Jia, X Dai, X Zhang - Molecular Oncology, 2024 - Wiley Online Library
Chimeric antigen receptor (CAR‐T) cell therapy is a newly developed immunotherapy
strategy and has achieved satisfactory outcomes in the treatment of hematological …

Current progress in chimeric antigen receptor T cell therapy for glioblastoma multiforme

HE Marei, A Althani, N Afifi, A Hasan, T Caceci… - Cancer …, 2021 - Wiley Online Library
Glioblastoma multiforme (GBM) is one of the deadliest brain tumors with an unfavorable
prognosis and overall survival of approximately 20 months following diagnosis. The current …