Quantitative serum nuclear magnetic resonance metabolomics in large-scale epidemiology: a primer on-omic technologies

P Würtz, AJ Kangas, P Soininen… - American journal of …, 2017 - academic.oup.com
Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …

Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics

P Soininen, AJ Kangas, P Würtz, T Suna… - Circulation …, 2015 - Am Heart Assoc
Metabolomics is becoming common in epidemiology due to recent developments in
quantitative profiling technologies and appealing results from their applications for …

Analytical methods in untargeted metabolomics: state of the art in 2015

A Alonso, S Marsal, A Julià - Frontiers in bioengineering and …, 2015 - frontiersin.org
Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …

Metabolic phenoty** in clinical and surgical environments

JK Nicholson, E Holmes, JM Kinross, AW Darzi… - Nature, 2012 - nature.com
Metabolic phenoty** involves the comprehensive analysis of biological fluids or tissue
samples. This analysis allows biochemical classification of a person's physiological or …

High resolution NMR spectroscopy as a structural and analytical tool for unsaturated lipids in solution

E Alexandri, R Ahmed, H Siddiqui, MI Choudhary… - Molecules, 2017 - mdpi.com
Mono-and polyunsaturated lipids are widely distributed in Nature, and are structurally and
functionally a diverse class of molecules with a variety of physicochemical, biological …

NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review

A Smolinska, L Blanchet, LMC Buydens… - Analytica chimica …, 2012 - Elsevier
Metabolomics is the discipline where endogenous and exogenous metabolites are
assessed, identified and quantified in different biological samples. Metabolites are crucial …

High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism

P Soininen, AJ Kangas, P Würtz, T Tukiainen… - Analyst, 2009 - pubs.rsc.org
A high-throughput proton (1H) nuclear magnetic resonance (NMR) metabonomics approach
is introduced to characterise systemic metabolic phenotypes. The methodology combines …

Chemometrics in metabolomics—a review in human disease diagnosis

R Madsen, T Lundstedt, J Trygg - Analytica chimica acta, 2010 - Elsevier
Metabolomics is a post genomic research field concerned with develo** methods for
analysis of low molecular weight compounds in biological systems, such as cells, organs or …

[HTML][HTML] Statistical methods for the analysis of high-throughput metabolomics data

J Bartel, J Krumsiek, FJ Theis - Computational and structural biotechnology …, 2013 - Elsevier
Metabolomics is a relatively new high-throughput technology that aims at measuring all
endogenous metabolites within a biological sample in an unbiased fashion. The resulting …

NMR-based metabolomics in human disease diagnosis: applications, limitations, and recommendations

AHM Emwas, RM Salek, JL Griffin, J Merzaban - Metabolomics, 2013 - Springer
Metabolomics is a dynamic and emerging research field, similar to proteomics,
transcriptomics and genomics in affording global understanding of biological systems. It is …