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The role of ErbB4 in cance r
VFM Segers, L Dugaucquier, E Feyen, H Shakeri… - Cellular oncology, 2020 - Springer
Background The epidermal growth factor receptor family consists of four members, ErbB1
(epidermal growth factor receptor-1), ErbB2, ErbB3, and ErbB4, which all have been found …
(epidermal growth factor receptor-1), ErbB2, ErbB3, and ErbB4, which all have been found …
The yin and yang of ERBB4: tumor suppressor and oncoprotein
Abstract ERBB4 (HER4) is a member of the ERBB family of receptor tyrosine kinases, a
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …
Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities
Triple-negative breast cancer (TNBC) is characterized by the absence of expression of
estrogen receptor, progesterone receptor, and HER-2. Thirty percent of patients recur after …
estrogen receptor, progesterone receptor, and HER-2. Thirty percent of patients recur after …
ErbB1-4-dependent EGF/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson's disease
Ligands for ErbB1-4 receptor tyrosine kinases, such as epidermal growth factor (EGF) and
neuregulins, regulate brain development and function. Thus, abnormalities in their signaling …
neuregulins, regulate brain development and function. Thus, abnormalities in their signaling …
Resveratrol and prostate cancer: promising role for microRNAs
Abstract Scope: Resveratrol (Res) has anticancer activity in prostate cancer (PCa), which
can be attributed to modulation of microRNAs (miRNAs/miRs). miRNAs/miRs are small non …
can be attributed to modulation of microRNAs (miRNAs/miRs). miRNAs/miRs are small non …
Membrane proteins: the key players of a cancer cell
KR Kampen - The Journal of membrane biology, 2011 - Springer
Membrane proteins are involved in the prognosis of the most common forms of cancer.
Membrane proteins are the hallmark of a cancer cell. The overexpressed membrane …
Membrane proteins are the hallmark of a cancer cell. The overexpressed membrane …
Anticancer natural compounds as epigenetic modulators of gene expression
E A. Ratovitski - Current Genomics, 2017 - benthamdirect.com
Accumulating evidence shows that hallmarks of cancer include:“genetic and epigenetic
alterations leading to inactivation of cancer suppressors, overexpression of oncogenes …
alterations leading to inactivation of cancer suppressors, overexpression of oncogenes …
ERBB 4 confers metastatic capacity in ewing sarcoma
A Mendoza‐Naranjo, A El‐Naggar, DH Wai… - EMBO molecular …, 2013 - embopress.org
Metastatic spread is the single‐most powerful predictor of poor outcome in Ewing sarcoma
(ES). Therefore targeting pathways that drive metastasis has tremendous potential to reduce …
(ES). Therefore targeting pathways that drive metastasis has tremendous potential to reduce …
ERBB oncogene proteins as targets for monoclonal antibodies
OL Polanovski, EN Lebedenko, SM Deyev - Biochemistry (Moscow), 2012 - Springer
General properties of the family of tyrosine kinase ERBB receptors are considered in
connection with their role in the generation of cascades of signal transduction in normal and …
connection with their role in the generation of cascades of signal transduction in normal and …
Aberrant promoter CpG methylation and its translational applications in breast cancer
Breast cancer is a complex disease driven by multiple factors including both genetic and
epigenetic alterations. Recent studies revealed that abnormal gene expression induced by …
epigenetic alterations. Recent studies revealed that abnormal gene expression induced by …