The development of microbubble contrast agents has broadened the scope of medical
ultrasound imaging. Along with dedicated imaging techniques, these agents provide …

Clinically significant portal hypertension is associated with an increased risk of develo**
gastro-oesophageal varices and hepatic decompensation. Hepatic venous pressure …

Noninvasive diagnostics for portal hypertension include imaging and functional tests, as well
as blood-based biomarkers, and capture different features of the portal hypertensive …

Background Liver cirrhosis is the fourth cause of death in adults in Western countries, with
complications of portal hypertension being responsible for most casualties. In order to …

Ultrasound contrast agent microbubbles have expanded the utility of biomedical ultrasound
from anatomic imaging to the assessment of microvascular blood flow characteristics and …

The natural history of chronic liver disease is characterized by a long asymptomatic or
compensated phase. During this long phase, fibrosis progresses eventually leading to …

Portal hypertension (PH) has traditionally been observed as a consequence of significant
fibrosis and cirrhosis in advanced non-alcoholic fatty liver disease (NAFLD). However …

Background The current standard for assessing the severity of portal hypertension is the
invasive acquisition of hepatic venous pressure gradient (HVPG). A noninvasive US-based …

Portal hypertension is the cause of the clinical complications associated with cirrhosis. The
primary complications of portal hypertension are ascites, acute variceal bleed, and hepatic …

Transjugular liver biopsy is a safe, effective and well-tolerated technique to obtain liver
tissue specimens in patients with diffuse liver disease associated with severe …