Effects of air pollution particles (ultrafine and fine particulate matter) on mitochondrial function and oxidative stress–Implications for cardiovascular and …

A Daiber, M Kuntic, O Hahad, LG Delogu… - Archives of biochemistry …, 2020 - Elsevier
Environmental pollution is a major cause of global mortality and burden of disease. All
chemical pollution forms together may be responsible for up to 12 million annual excess …

Novel strategies for disrupting cancer-cell functions with mitochondria-targeted antitumor drug–loaded nanoformulations

KS Allemailem, A Almatroudi, MA Alsahli… - International Journal …, 2021 - Taylor & Francis
Any variation in normal cellular function results in mitochondrial dysregulation that occurs in
several diseases, including cancer. Such processes as oxidative stress, metabolism …

Chitosan, Polyethylene Glycol and Polyvinyl Alcohol Modified MgFe2O4 Ferrite Magnetic Nanoparticles in Doxorubicin Delivery: A Comparative Study In Vitro

D Ramnandan, S Mokhosi, A Daniels, M Singh - Molecules, 2021 - mdpi.com
Cancer-based magnetic theranostics has gained significant interest in recent years and can
contribute as an influential archetype in the effective treatment of cancer. Owing to their …

Oxygen tank for synergistic hypoxia relief to enhance mitochondria-targeted photodynamic therapy

X Li, H Wang, Z Li, D Li, X Lu, S Ai, Y Dong… - Biomaterials …, 2022 - spj.science.org
Background Mitochondria play an essential role in cellular redox homeostasis maintenance
and meanwhile serve as an important target for organelle targeted therapy. Photodynamic …

Modified gold nanoparticles for efficient delivery of betulinic acid to cancer cell mitochondria

O Oladimeji, J Akinyelu, A Daniels, M Singh - International Journal of …, 2021 - mdpi.com
Advances in nanomedicine have seen the adaptation of nanoparticles (NPs) for subcellular
delivery for enhanced therapeutic impact and reduced side effects. The pivotal role of the …

Mitochondrial noncoding RNAs: new wine in an old bottle

H Liang, J Liu, S Su, Q Zhao - RNA biology, 2021 - Taylor & Francis
Mitochondrial noncoding RNAs (mt-ncRNAs) include noncoding RNAs inside the
mitochondria that are transcribed from the mitochondrial genome or nuclear genome, and …

Advances in next-generation lipid-polymer hybrid nanocarriers with emphasis on polymer-modified functional liposomes and cell-based-biomimetic nanocarriers for …

Y Liu, X **e, H Chen, X Hou, Y He, J Shen, J Shi… - … , Biology and Medicine, 2020 - Elsevier
Recently, functional liposomes modified with versatile polymer and cell-based-biomimetic
nanoparticles have emerged as the most advanced lipid-polymer hybrid nanocarriers …

Co-polymer functionalised gold nanoparticles show efficient mitochondrial targeted drug delivery in cervical carcinoma cells

O Oladimeji, J Akinyelu, M Singh - Journal of Biomedical …, 2020 - ingentaconnect.com
The mitochondria have recently become a novel target in the treatment of cancer. Targeted
delivery by nanoparticles (NPs) has shown potential in enhancing existing therapeutic …

[PDF][PDF] Polymeric mesoporous silica nanoparticles for combination drug delivery in vitro

T Moodley, M Singh - Biointerface Res. Appl. Chem, 2020 - researchgate.net
Despite the recent advances and development of conventional cancer therapy strategies,
treatments often lack specificity, resulting in low therapeutic efficiency, cancer recurrence …

Localized nano-mediated interleukin-12 gene therapy: Promising candidate for cancer immunotherapeutics

J Venkatas, M Singh - Current Cancer Drug Targets, 2022 - benthamdirect.com
Background: Interleukin-12 (IL-12) has a pleiotropic nature that allows it to induce immune
responses while reversing tumour-induced immunosuppression. Therefore, this paper …