Modern quantitative image analysis techniques have enabled high-throughput, high-content
imaging experiments. Image-based profiling leverages the rich information in images to …

High-throughput image-based profiling platforms are powerful technologies capable of
collecting data from billions of cells exposed to thousands of perturbations in a time-and cost …

Morphological profiling is a valuable tool in phenotypic drug discovery. The advent of high-
throughput automated imaging has enabled the capturing of a wide range of morphological …

Early derisking decisions in the development of new chemical compounds enable the
identification of novel chemical candidates with improved safety profiles. In vivo studies are …

A key challenge of the modern genomics era is develo** empirical data-driven
representations of gene function. Here we present the first unbiased morphology-based …

Motivation High-throughput time-lapse imaging is a fundamental tool for efficient living cell
profiling at single-cell resolution. Label-free phase-contrast video microscopy enables …

In profiling assays, thousands of biological properties are measured in a single test, yielding
biological discoveries by capturing the state of a cell population, often at the single-cell level …

Pyroptosis represents one type of Programmed Cell Death (PCD). It is a form of inflammatory
cell death that is canonically defined by caspase-1 cleavage and Gasdermin-mediated …

Cell Painting images offer valuable insights into the state of a cell and enable many
biological applications, but publicly available arrayed datasets only include hundreds of …

Image-based profiling has been used to analyze cell health, drug mechanism of action,
CRISPR-edited cells, and overall cytotoxicity. Cell Painting is a broadly used image-based …